Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning
Neutral networks, which are sets of genotypes connected via single mutations that share the same phenotype, are important for evolvability. Here, the authors provide experimental evidence of a neutral network in an RNA enzyme using a high-throughput assay and deep learning.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32538-z |
| _version_ | 1828150742273228800 |
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| author | Rachapun Rotrattanadumrong Yohei Yokobayashi |
| author_facet | Rachapun Rotrattanadumrong Yohei Yokobayashi |
| author_sort | Rachapun Rotrattanadumrong |
| collection | DOAJ |
| description | Neutral networks, which are sets of genotypes connected via single mutations that share the same phenotype, are important for evolvability. Here, the authors provide experimental evidence of a neutral network in an RNA enzyme using a high-throughput assay and deep learning. |
| first_indexed | 2024-04-11T21:47:33Z |
| format | Article |
| id | doaj.art-30192a0a88c148c6b5f0d232be96ce71 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T21:47:33Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-30192a0a88c148c6b5f0d232be96ce712022-12-22T04:01:23ZengNature PortfolioNature Communications2041-17232022-08-0113111410.1038/s41467-022-32538-zExperimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learningRachapun Rotrattanadumrong0Yohei Yokobayashi1Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate UniversityNucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate UniversityNeutral networks, which are sets of genotypes connected via single mutations that share the same phenotype, are important for evolvability. Here, the authors provide experimental evidence of a neutral network in an RNA enzyme using a high-throughput assay and deep learning.https://doi.org/10.1038/s41467-022-32538-z |
| spellingShingle | Rachapun Rotrattanadumrong Yohei Yokobayashi Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning Nature Communications |
| title | Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning |
| title_full | Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning |
| title_fullStr | Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning |
| title_full_unstemmed | Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning |
| title_short | Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning |
| title_sort | experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning |
| url | https://doi.org/10.1038/s41467-022-32538-z |
| work_keys_str_mv | AT rachapunrotrattanadumrong experimentalexplorationofaribozymeneutralnetworkusingevolutionaryalgorithmanddeeplearning AT yoheiyokobayashi experimentalexplorationofaribozymeneutralnetworkusingevolutionaryalgorithmanddeeplearning |