Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations
Phytochemicals are compounds found in plants that possess a variety of bioactive properties, including antioxidant and immunomodulatory properties. Recent studies have highlighted the potential of phytochemicals in targeting specific signalling pathways involved in cytokine storm, a life-threatening...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tabriz University of Medical Sciences
2024-03-01
|
| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-14-105.pdf |
| _version_ | 1797216884850950144 |
|---|---|
| author | Abdusalam Abdullah Alarabei Nur Aimi Liyana Abd Aziz Nur Izah AB Razak Razif Abas Hasnah Bahari Maizaton Atmadini Abdullah Mohd Khairi Hussain Amin Malik Shah Abdul Majid Rusliza Basir |
| author_facet | Abdusalam Abdullah Alarabei Nur Aimi Liyana Abd Aziz Nur Izah AB Razak Razif Abas Hasnah Bahari Maizaton Atmadini Abdullah Mohd Khairi Hussain Amin Malik Shah Abdul Majid Rusliza Basir |
| author_sort | Abdusalam Abdullah Alarabei |
| collection | DOAJ |
| description | Phytochemicals are compounds found in plants that possess a variety of bioactive properties, including antioxidant and immunomodulatory properties. Recent studies have highlighted the potential of phytochemicals in targeting specific signalling pathways involved in cytokine storm, a life-threatening clinical condition resulting from excessive immune cell activation and oversupply of proinflammatory cytokines. Several studies have documented the immunomodulatory effects of phytochemicals on immune function, including their ability to regulate essential cellular and molecular interactions of immune system cells. This makes them a promising alternative for cytokine storm management, especially when combined with existing chemotherapies. Furthermore, phytochemicals have been found to target multiple signalling pathways, including the TNF-α/NF-κB, IL-1/NF-κB, IFN-γ/JAK/STAT, and IL-6/JAK-STAT. These pathways play critical roles in the development and progression of cytokine storm, and targeting them with phytochemicals represents a promising strategy for controlling cytokine release and the subsequent inflammation. Studies have also investigated certain families of plant-related constituents and their potential immunomodulatory actions. In vivo and in vitro studies have reported the immunomodulatory effects of phytochemicals, which provide viable alternatives in the management of cytokine storm syndrome. The collective data from previous studies suggest that phytochemicals represent a potentially functional source of cytokine storm treatment and promote further exploration of these compounds as immunomodulatory agents for suppressing specific signalling cascade responses. Overall, the previous research findings support the use of phytochemicals as a complementary approach in managing cytokine storm and improving patient outcomes. |
| first_indexed | 2024-04-24T11:53:04Z |
| format | Article |
| id | doaj.art-301a940634ee4a8faf01361ffddf2ee2 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-04-24T11:53:04Z |
| publishDate | 2024-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-301a940634ee4a8faf01361ffddf2ee22024-04-09T06:11:29ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082024-03-0114110511910.34172/apb.2024.001apb-39674Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm SituationsAbdusalam Abdullah Alarabei0Nur Aimi Liyana Abd Aziz1Nur Izah AB Razak2Razif Abas3Hasnah Bahari4Maizaton Atmadini Abdullah5Mohd Khairi Hussain6Amin Malik Shah Abdul Majid7Rusliza Basir8Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Natureceuticals Sdn Bhd, Kedah Halal Park, Kawasan Perindustrian Sg. Petani, 08000 Sg. Petani, Kedah, Malaysia.Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.Phytochemicals are compounds found in plants that possess a variety of bioactive properties, including antioxidant and immunomodulatory properties. Recent studies have highlighted the potential of phytochemicals in targeting specific signalling pathways involved in cytokine storm, a life-threatening clinical condition resulting from excessive immune cell activation and oversupply of proinflammatory cytokines. Several studies have documented the immunomodulatory effects of phytochemicals on immune function, including their ability to regulate essential cellular and molecular interactions of immune system cells. This makes them a promising alternative for cytokine storm management, especially when combined with existing chemotherapies. Furthermore, phytochemicals have been found to target multiple signalling pathways, including the TNF-α/NF-κB, IL-1/NF-κB, IFN-γ/JAK/STAT, and IL-6/JAK-STAT. These pathways play critical roles in the development and progression of cytokine storm, and targeting them with phytochemicals represents a promising strategy for controlling cytokine release and the subsequent inflammation. Studies have also investigated certain families of plant-related constituents and their potential immunomodulatory actions. In vivo and in vitro studies have reported the immunomodulatory effects of phytochemicals, which provide viable alternatives in the management of cytokine storm syndrome. The collective data from previous studies suggest that phytochemicals represent a potentially functional source of cytokine storm treatment and promote further exploration of these compounds as immunomodulatory agents for suppressing specific signalling cascade responses. Overall, the previous research findings support the use of phytochemicals as a complementary approach in managing cytokine storm and improving patient outcomes.https://apb.tbzmed.ac.ir/PDF/apb-14-105.pdfcytokinescytokine release syndromecytokine stormimmunomodulationinflammatory pathwaysphytochemicals |
| spellingShingle | Abdusalam Abdullah Alarabei Nur Aimi Liyana Abd Aziz Nur Izah AB Razak Razif Abas Hasnah Bahari Maizaton Atmadini Abdullah Mohd Khairi Hussain Amin Malik Shah Abdul Majid Rusliza Basir Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations Advanced Pharmaceutical Bulletin cytokines cytokine release syndrome cytokine storm immunomodulation inflammatory pathways phytochemicals |
| title | Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations |
| title_full | Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations |
| title_fullStr | Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations |
| title_full_unstemmed | Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations |
| title_short | Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations |
| title_sort | immunomodulating phytochemicals an insight into their potential use in cytokine storm situations |
| topic | cytokines cytokine release syndrome cytokine storm immunomodulation inflammatory pathways phytochemicals |
| url | https://apb.tbzmed.ac.ir/PDF/apb-14-105.pdf |
| work_keys_str_mv | AT abdusalamabdullahalarabei immunomodulatingphytochemicalsaninsightintotheirpotentialuseincytokinestormsituations AT nuraimiliyanaabdaziz immunomodulatingphytochemicalsaninsightintotheirpotentialuseincytokinestormsituations AT nurizahabrazak immunomodulatingphytochemicalsaninsightintotheirpotentialuseincytokinestormsituations AT razifabas immunomodulatingphytochemicalsaninsightintotheirpotentialuseincytokinestormsituations AT hasnahbahari immunomodulatingphytochemicalsaninsightintotheirpotentialuseincytokinestormsituations AT maizatonatmadiniabdullah immunomodulatingphytochemicalsaninsightintotheirpotentialuseincytokinestormsituations AT mohdkhairihussain immunomodulatingphytochemicalsaninsightintotheirpotentialuseincytokinestormsituations AT aminmalikshahabdulmajid immunomodulatingphytochemicalsaninsightintotheirpotentialuseincytokinestormsituations AT ruslizabasir immunomodulatingphytochemicalsaninsightintotheirpotentialuseincytokinestormsituations |