Identifying Typical Presentations of Vitamin B-12 Deficiency among Individuals Attending Tertiary Care Hospital in Central Gujarat: A Case Control Study
inadequate intake leads to haematological and neurological disorders. Objective:To determine the symptoms and signs associated with Vitamin B12 deficiency. Method: A case control study was conducted at the medicine department of tertiary care hospital. Patients visiting hospital with serum Vitamin B...
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| Format: | Article |
| Language: | English |
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Indian Association of Preventive and Social Medicine
2024-03-01
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| Series: | Healthline |
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| Online Access: | https://www.healthlinejournal.org/index_pdf/518.pdf |
| _version_ | 1797194308583948288 |
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| author | Sangita V. Patel Alpesh B. Makwana Archana U. Gandhi Latika T. Chugh Vipul Bhavsar |
| author_facet | Sangita V. Patel Alpesh B. Makwana Archana U. Gandhi Latika T. Chugh Vipul Bhavsar |
| author_sort | Sangita V. Patel |
| collection | DOAJ |
| description | inadequate intake leads to haematological and neurological disorders. Objective:To determine the symptoms and signs associated with Vitamin B12 deficiency. Method: A case control study was conducted at the medicine department of tertiary care hospital. Patients visiting hospital with serum Vitamin B12 level below 200pg/ml were labelled as cases and more than 200 pg/ml were labelled as controls, irrespective of signs and symptoms of Vitamin B 12 deficiency.Controls were matched for age to minimize confounding. 160 cases and 160 controls were selected. Pretested semi structured questionnaire was used to identify signs and symptoms of Vitamin B12 deficiency among cases and controls. Chi square test was applied for each symptom between cases and control, of which 10 were significant (p<0.05). ROC curve was plotted for the 10 symptoms to check their usefulness for diagnosing vitamin B12 deficiency. Results: Area-Under Curve (AUC) was maximum under knuckle pigmentation (0.794), (Positive Likelihood Ratio (PLR)=3.24) followed by poor memory (0.684), (PLR=3.25) tingling and numbness (0.624), (PLR=1.84) and dizziness (0.605), (PLR=1.38) in respective order. Whereas fatigue, sore and swollen tongue, pale skin, breathlessness, palpitation, insomnia, memory loss were not associated with Vitamin B12 deficiency(p>0.05).Conclusion: Presence of knuckle pigmentation, poor memory, tingling and numbness, and dizziness can be defined as hallmarks of Vitamin B12 deficiency and can be used to predict and start Vitamin B12 supplementation. |
| first_indexed | 2024-04-24T05:54:13Z |
| format | Article |
| id | doaj.art-301cb079cfce4a7286da695fceae1b5e |
| institution | Directory Open Access Journal |
| issn | 2229-337X 2320-1525 |
| language | English |
| last_indexed | 2024-04-24T05:54:13Z |
| publishDate | 2024-03-01 |
| publisher | Indian Association of Preventive and Social Medicine |
| record_format | Article |
| series | Healthline |
| spelling | doaj.art-301cb079cfce4a7286da695fceae1b5e2024-04-23T09:13:26ZengIndian Association of Preventive and Social MedicineHealthline2229-337X2320-15252024-03-01151313910.51957/Healthline_590_2024Identifying Typical Presentations of Vitamin B-12 Deficiency among Individuals Attending Tertiary Care Hospital in Central Gujarat: A Case Control StudySangita V. Patel0Alpesh B. Makwana1Archana U. Gandhi2Latika T. Chugh3Vipul Bhavsar 4Associate Professor, Department of Community Medicine, Medical College, Baroda, Gujarat, India District Quality Medical Oficer, Kheda District Panchayat, NadiadAssociate Professor, Department of Medicine, Medical College, Baroda, Gujarat, IndiaSenior Resident, Department of Community Medicine, Medical College, Baroda, Gujarat, India Physician, Rushabh clinic, Baroda, Gujarat ,Indiainadequate intake leads to haematological and neurological disorders. Objective:To determine the symptoms and signs associated with Vitamin B12 deficiency. Method: A case control study was conducted at the medicine department of tertiary care hospital. Patients visiting hospital with serum Vitamin B12 level below 200pg/ml were labelled as cases and more than 200 pg/ml were labelled as controls, irrespective of signs and symptoms of Vitamin B 12 deficiency.Controls were matched for age to minimize confounding. 160 cases and 160 controls were selected. Pretested semi structured questionnaire was used to identify signs and symptoms of Vitamin B12 deficiency among cases and controls. Chi square test was applied for each symptom between cases and control, of which 10 were significant (p<0.05). ROC curve was plotted for the 10 symptoms to check their usefulness for diagnosing vitamin B12 deficiency. Results: Area-Under Curve (AUC) was maximum under knuckle pigmentation (0.794), (Positive Likelihood Ratio (PLR)=3.24) followed by poor memory (0.684), (PLR=3.25) tingling and numbness (0.624), (PLR=1.84) and dizziness (0.605), (PLR=1.38) in respective order. Whereas fatigue, sore and swollen tongue, pale skin, breathlessness, palpitation, insomnia, memory loss were not associated with Vitamin B12 deficiency(p>0.05).Conclusion: Presence of knuckle pigmentation, poor memory, tingling and numbness, and dizziness can be defined as hallmarks of Vitamin B12 deficiency and can be used to predict and start Vitamin B12 supplementation.https://www.healthlinejournal.org/index_pdf/518.pdfindiatertiary hospitaldiagnostic algorithmvitamin b12 deficiency |
| spellingShingle | Sangita V. Patel Alpesh B. Makwana Archana U. Gandhi Latika T. Chugh Vipul Bhavsar Identifying Typical Presentations of Vitamin B-12 Deficiency among Individuals Attending Tertiary Care Hospital in Central Gujarat: A Case Control Study Healthline india tertiary hospital diagnostic algorithm vitamin b12 deficiency |
| title | Identifying Typical Presentations of Vitamin B-12 Deficiency among Individuals Attending Tertiary Care Hospital in Central Gujarat: A Case Control Study |
| title_full | Identifying Typical Presentations of Vitamin B-12 Deficiency among Individuals Attending Tertiary Care Hospital in Central Gujarat: A Case Control Study |
| title_fullStr | Identifying Typical Presentations of Vitamin B-12 Deficiency among Individuals Attending Tertiary Care Hospital in Central Gujarat: A Case Control Study |
| title_full_unstemmed | Identifying Typical Presentations of Vitamin B-12 Deficiency among Individuals Attending Tertiary Care Hospital in Central Gujarat: A Case Control Study |
| title_short | Identifying Typical Presentations of Vitamin B-12 Deficiency among Individuals Attending Tertiary Care Hospital in Central Gujarat: A Case Control Study |
| title_sort | identifying typical presentations of vitamin b 12 deficiency among individuals attending tertiary care hospital in central gujarat a case control study |
| topic | india tertiary hospital diagnostic algorithm vitamin b12 deficiency |
| url | https://www.healthlinejournal.org/index_pdf/518.pdf |
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