Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats
Sodium benzoate SB is a white powder, used as preservative and food additive. Biochemical, physiological and histopathological effects of SB been tested in adult male rats. Twenty-four adult albino male rats aged100 day and weighted 250-350 g were used. Animals were divided into 4 groups. The first...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2022-04-01
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| Series: | Iraqi Journal of Veterinary Sciences |
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| Online Access: | https://vetmedmosul.com/article_172971_ab5f59134e6b39b7e50e2bf9c2444208.pdf |
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| author | Safa A. Al-Ameen Eman H. Jirjees Fadwa Kh. Tawfeeq |
| author_facet | Safa A. Al-Ameen Eman H. Jirjees Fadwa Kh. Tawfeeq |
| author_sort | Safa A. Al-Ameen |
| collection | DOAJ |
| description | Sodium benzoate SB is a white powder, used as preservative and food additive. Biochemical, physiological and histopathological effects of SB been tested in adult male rats. Twenty-four adult albino male rats aged100 day and weighted 250-350 g were used. Animals were divided into 4 groups. The first group considered as control, which received normal saline orally, other groups treated with SB by 300, 400, 500 mg/Kg of body weight respectively for 30 days. At the end of experiment, blood samples were collected from retro orbital sinus. Heart, liver, spleen, kidneys and brain were obtained for weight recording. The results indicated a significant decrease of super oxide dismutase SOD activity and a significant increase of nitric oxide NO level of treated group 500 mg/Kg of body weight. Moreover, findings revealed that there are no significant changes in growth hormone GH activity and body weight. A significant reduction of heart weight of treated group 500 mg/Kg of body weight were observed. The histopathological changes ranged from mild to severe in the brain cortex, as focal gliosis, satellitosis, mild vacuolation and vasogenic edema in treated groups with SB by different doses. Also, some changes were observed in liver represented by congestion of portal vein, mild hydropic degeneration of hepatocytes, stenosis of sinusoids, steatosis and necrosis of hepatocytes in treated groups with SB compared to control group. It concluded that short-term exposure to high doses of SB may be considered an oxidant substance that caused oxidative stress. Furthermore, SB can harm various organs in the body. |
| first_indexed | 2024-12-18T05:23:25Z |
| format | Article |
| id | doaj.art-301d5468da824eb8b134c322ed706309 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-12-18T05:23:25Z |
| publishDate | 2022-04-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-301d5468da824eb8b134c322ed7063092022-12-21T21:19:35ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552022-04-0136226727210.33899/ijvs.2021.129935.1705172971Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male ratsSafa A. Al-Ameen0Eman H. Jirjees1Fadwa Kh. Tawfeeq2Department of Chemistry, Science College, University of Mosul, Mosul, IraqDepartment of Dental Industry Techniques, Al-Noor University College, Mosul, IraqDepartment of Biochemistry, Physiology and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqSodium benzoate SB is a white powder, used as preservative and food additive. Biochemical, physiological and histopathological effects of SB been tested in adult male rats. Twenty-four adult albino male rats aged100 day and weighted 250-350 g were used. Animals were divided into 4 groups. The first group considered as control, which received normal saline orally, other groups treated with SB by 300, 400, 500 mg/Kg of body weight respectively for 30 days. At the end of experiment, blood samples were collected from retro orbital sinus. Heart, liver, spleen, kidneys and brain were obtained for weight recording. The results indicated a significant decrease of super oxide dismutase SOD activity and a significant increase of nitric oxide NO level of treated group 500 mg/Kg of body weight. Moreover, findings revealed that there are no significant changes in growth hormone GH activity and body weight. A significant reduction of heart weight of treated group 500 mg/Kg of body weight were observed. The histopathological changes ranged from mild to severe in the brain cortex, as focal gliosis, satellitosis, mild vacuolation and vasogenic edema in treated groups with SB by different doses. Also, some changes were observed in liver represented by congestion of portal vein, mild hydropic degeneration of hepatocytes, stenosis of sinusoids, steatosis and necrosis of hepatocytes in treated groups with SB compared to control group. It concluded that short-term exposure to high doses of SB may be considered an oxidant substance that caused oxidative stress. Furthermore, SB can harm various organs in the body.https://vetmedmosul.com/article_172971_ab5f59134e6b39b7e50e2bf9c2444208.pdfsodium benzoategrowth hormonenitric oxide |
| spellingShingle | Safa A. Al-Ameen Eman H. Jirjees Fadwa Kh. Tawfeeq Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats Iraqi Journal of Veterinary Sciences sodium benzoate growth hormone nitric oxide |
| title | Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats |
| title_full | Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats |
| title_fullStr | Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats |
| title_full_unstemmed | Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats |
| title_short | Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats |
| title_sort | effect of sodium benzoate on some biochemical physiological and histopathological aspects in adult male rats |
| topic | sodium benzoate growth hormone nitric oxide |
| url | https://vetmedmosul.com/article_172971_ab5f59134e6b39b7e50e2bf9c2444208.pdf |
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