4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A

4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A

Merkel cell carcinoma (MCC) is frequently caused by the Merkel cell polyomavirus (MCPyV), and MCPyV-positive tumor cells depend on expression of the virus-encoded T antigens (TA). Here, we identify 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone (PHT)—a reported inhibitor of Aurora kin...

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Bibliographic Details
Main Authors: Roland Houben, Pamela Alimova, Bhavishya Sarma, Sonja Hesbacher, Carolin Schulte, Eva-Maria Sarosi, Christian Adam, Thibault Kervarrec, David Schrama
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cancers
Subjects:
Merkel cell carcinoma
polyomavirus
large T antigen
phthalazinone pyrazole
glycogen synthase kinase 3
GSK3
Online Access:https://www.mdpi.com/2072-6694/15/9/2542

Internet

https://www.mdpi.com/2072-6694/15/9/2542

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