<b>Physical activity level of three generation families. Genetic and environmental factors</b>
This study aims (1) to investigate the presence of familial aggregation in physical activity (PA) levels and sedentary behavior (SB) among members of three generations families and (2) to estimate the magnitude of additive genetic influences on PA and SB phenotypes. The sample consisted of 100 exten...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Santa Catarina
2010-09-01
|
| Series: | Revista Brasileira de Cineantropometria e Desempenho Humano |
| Subjects: | |
| Online Access: | http://www.periodicos.ufsc.br/index.php/rbcdh/article/view/12353/13516 |
| _version_ | 1818133588001947648 |
|---|---|
| author | Raquel Nichele de Chaves José António Ribeiro Maia Rui Garganta Michele Caroline de Souza Daniel Santos André Seabra |
| author_facet | Raquel Nichele de Chaves José António Ribeiro Maia Rui Garganta Michele Caroline de Souza Daniel Santos André Seabra |
| author_sort | Raquel Nichele de Chaves |
| collection | DOAJ |
| description | This study aims (1) to investigate the presence of familial aggregation in physical activity (PA) levels and sedentary behavior (SB) among members of three generations families and (2) to estimate the magnitude of additive genetic influences on PA and SB phenotypes. The sample consisted of 100 extended families covering three generations (n=1034), from the Lisbon area, Portugal. Phenotypes were assessed via the short version of the self-administered International Physical Activity Questionnaire (IPAQ-SF). Measured phenotypes: total physical activity (TPA); vigorous (VPA); moderate (MPA); walking; time spent in sitting time (ST), watching television (WT) and PA levels classification. Body mass index (BMI) was calculated. Exploratory family analysis in all phenotypes was conducted in PEDSTATS software. The genetic component (h2) and shared environmental effect were estimated using maximum likelihood implemented in the SOLAR software package. All graphs were done in HLM software. Sex, age, sex*age, age2, sex*age2 and BMI were used as covariates. Significant level was set at 0,05. Genetic component estimates (h2) were as follows: TPA h2=0,28±0,06 (p<0.0001); VPA h2=0,35±0,06 (p<0.0001); MPA h2=0,29±0,06 (p<0.0001); walking h2=0,40±0,06 (p<0.0001); ST h2=0,29±0,06 (p<0.0001); WT h2=0,15±0,06 (p<0.003) and determination of the level physical activity h2=0,35±0,14 (p<0.007). Shared environmental effect was not significant. These results showed a low-to-moderate genetic contribution, between 15% to 40% of the total variability, in the PA and SB phenotypes. The genetic factors have low to moderate influence in this sample. Non-shared environmental factors appear to have the major contribution in these phenotypes. |
| first_indexed | 2024-12-11T08:55:06Z |
| format | Article |
| id | doaj.art-302114985e504d09bf5b9e83fa676d60 |
| institution | Directory Open Access Journal |
| issn | 1415-8426 1980-0037 |
| language | English |
| last_indexed | 2024-12-11T08:55:06Z |
| publishDate | 2010-09-01 |
| publisher | Universidade Federal de Santa Catarina |
| record_format | Article |
| series | Revista Brasileira de Cineantropometria e Desempenho Humano |
| spelling | doaj.art-302114985e504d09bf5b9e83fa676d602022-12-22T01:13:55ZengUniversidade Federal de Santa CatarinaRevista Brasileira de Cineantropometria e Desempenho Humano1415-84261980-00372010-09-01126408414<b>Physical activity level of three generation families. Genetic and environmental factors</b>Raquel Nichele de ChavesJosé António Ribeiro MaiaRui GargantaMichele Caroline de SouzaDaniel SantosAndré SeabraThis study aims (1) to investigate the presence of familial aggregation in physical activity (PA) levels and sedentary behavior (SB) among members of three generations families and (2) to estimate the magnitude of additive genetic influences on PA and SB phenotypes. The sample consisted of 100 extended families covering three generations (n=1034), from the Lisbon area, Portugal. Phenotypes were assessed via the short version of the self-administered International Physical Activity Questionnaire (IPAQ-SF). Measured phenotypes: total physical activity (TPA); vigorous (VPA); moderate (MPA); walking; time spent in sitting time (ST), watching television (WT) and PA levels classification. Body mass index (BMI) was calculated. Exploratory family analysis in all phenotypes was conducted in PEDSTATS software. The genetic component (h2) and shared environmental effect were estimated using maximum likelihood implemented in the SOLAR software package. All graphs were done in HLM software. Sex, age, sex*age, age2, sex*age2 and BMI were used as covariates. Significant level was set at 0,05. Genetic component estimates (h2) were as follows: TPA h2=0,28±0,06 (p<0.0001); VPA h2=0,35±0,06 (p<0.0001); MPA h2=0,29±0,06 (p<0.0001); walking h2=0,40±0,06 (p<0.0001); ST h2=0,29±0,06 (p<0.0001); WT h2=0,15±0,06 (p<0.003) and determination of the level physical activity h2=0,35±0,14 (p<0.007). Shared environmental effect was not significant. These results showed a low-to-moderate genetic contribution, between 15% to 40% of the total variability, in the PA and SB phenotypes. The genetic factors have low to moderate influence in this sample. Non-shared environmental factors appear to have the major contribution in these phenotypes.http://www.periodicos.ufsc.br/index.php/rbcdh/article/view/12353/13516Genetic epidemiologyPhysical activityHeritabilityEpidemiologia genéticaAtividade físicaHeritabilidade. |
| spellingShingle | Raquel Nichele de Chaves José António Ribeiro Maia Rui Garganta Michele Caroline de Souza Daniel Santos André Seabra <b>Physical activity level of three generation families. Genetic and environmental factors</b> Revista Brasileira de Cineantropometria e Desempenho Humano Genetic epidemiology Physical activity Heritability Epidemiologia genética Atividade física Heritabilidade. |
| title | <b>Physical activity level of three generation families. Genetic and environmental factors</b> |
| title_full | <b>Physical activity level of three generation families. Genetic and environmental factors</b> |
| title_fullStr | <b>Physical activity level of three generation families. Genetic and environmental factors</b> |
| title_full_unstemmed | <b>Physical activity level of three generation families. Genetic and environmental factors</b> |
| title_short | <b>Physical activity level of three generation families. Genetic and environmental factors</b> |
| title_sort | b physical activity level of three generation families genetic and environmental factors b |
| topic | Genetic epidemiology Physical activity Heritability Epidemiologia genética Atividade física Heritabilidade. |
| url | http://www.periodicos.ufsc.br/index.php/rbcdh/article/view/12353/13516 |
| work_keys_str_mv | AT raquelnicheledechaves bphysicalactivitylevelofthreegenerationfamiliesgeneticandenvironmentalfactorsb AT joseantonioribeiromaia bphysicalactivitylevelofthreegenerationfamiliesgeneticandenvironmentalfactorsb AT ruigarganta bphysicalactivitylevelofthreegenerationfamiliesgeneticandenvironmentalfactorsb AT michelecarolinedesouza bphysicalactivitylevelofthreegenerationfamiliesgeneticandenvironmentalfactorsb AT danielsantos bphysicalactivitylevelofthreegenerationfamiliesgeneticandenvironmentalfactorsb AT andreseabra bphysicalactivitylevelofthreegenerationfamiliesgeneticandenvironmentalfactorsb |