Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma

Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma

Abstract Background Esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of cancer-associated death worldwide with a dismal overall 5-year survival rate of less than 20%. The standard first-line therapy for advanced ESCC is concomitant chemo-radiation therapy (CCRT); however, patient...

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Bibliographic Details
Main Authors: Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan, Yi-Ching Wang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Biomedical Science
Subjects:
Chemoradiotherapy resistance
NRF2
SOX17
DNA methyltransferases
And esophageal squamous cell carcinoma
Online Access:https://doi.org/10.1186/s12929-022-00873-4

Internet

https://doi.org/10.1186/s12929-022-00873-4

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