Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System
In this work, the mesoporous silica nanoparticles (MSNs) of type MCM-41 were manufactured and modified with Fe3O4 to load curcumin (CUR) CUR@Fe3O4/MCM-41 as an efficient carrier in drug delivery systems. X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FT-IR),...
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| Format: | Article |
| Language: | English |
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Unviversity of Technology- Iraq
2022-03-01
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| Series: | Engineering and Technology Journal |
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| Online Access: | https://etj.uotechnology.edu.iq/article_173481_fc7310b390635480197a7cca453cc026.pdf |
| _version_ | 1797337670944292864 |
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| author | Nidhal Atiyah Mohammed Atiya Talib Albayati |
| author_facet | Nidhal Atiyah Mohammed Atiya Talib Albayati |
| author_sort | Nidhal Atiyah |
| collection | DOAJ |
| description | In this work, the mesoporous silica nanoparticles (MSNs) of type MCM-41 were manufactured and modified with Fe3O4 to load curcumin (CUR) CUR@Fe3O4/MCM-41 as an efficient carrier in drug delivery systems. X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FT-IR), and nitrogen adsorption-desorption isotherms were used to characterize the three samples: pure MCM-41, Fe3O4/MCM-41, & CUR@Fe3O4/MCM-41. Adsorption processes tests were carried out to determine the impact of various variables on the CUR load efficiency. These variables were the carrier dosage, pH, contact time, and initial CUR concentration. The maximal drug loading efficiencies (DL %) were 15.78 % and 22.98 %, respectively. According to the data, The Freundlich isotherm had a stronger correlation coefficient R2= 0.999 for MCM-41, while the Langmuir isotherm had a greater R2 of 0.9666 for Fe3O4/MCM-41. A pseudo-second-order kinetic model fits well with R2=0.9827 for MCM-41 and 0.9994 for Fe3O4/MCM-41. Phosphate Buffer Solution (PBS) with a pH of 7.4 was utilized to study CUR release behavior. According to the research, the maximum release for MCM-41 and Fe3O4/MCM-41 might be 74.1 % and 25.19 % after 72 h, respectively. Various kinetic release models were used, including First-order, Korsmeyer-Peppas, Hixson and Crowell, Higuchi, and Weibull. After 72h, the drug release data were fit using a Weibull kinetic model with an R2 of 0.944 and 0.764 for MCM-41 and Fe3O4/MCM-41, respectively. |
| first_indexed | 2024-03-08T09:16:57Z |
| format | Article |
| id | doaj.art-3021a92b372f4566b8dba2b39ccbf36f |
| institution | Directory Open Access Journal |
| issn | 1681-6900 2412-0758 |
| language | English |
| last_indexed | 2024-03-08T09:16:57Z |
| publishDate | 2022-03-01 |
| publisher | Unviversity of Technology- Iraq |
| record_format | Article |
| series | Engineering and Technology Journal |
| spelling | doaj.art-3021a92b372f4566b8dba2b39ccbf36f2024-01-31T14:27:44ZengUnviversity of Technology- IraqEngineering and Technology Journal1681-69002412-07582022-03-0140347248310.30684/etj.v40i3.2174173481Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery SystemNidhal Atiyah0Mohammed Atiya1Talib Albayati2Chemical Engineering Dept, University of Technology-Iraq, Alsina’a street, 10066 Baghdad, Iraq.Chemical Engineering, Al-Khawarizmi College of Engineering, University of Baghdad.Chemical Engineering Dept, University of Technology-Iraq, Alsina’a street, 10066 Baghdad, Iraq.In this work, the mesoporous silica nanoparticles (MSNs) of type MCM-41 were manufactured and modified with Fe3O4 to load curcumin (CUR) CUR@Fe3O4/MCM-41 as an efficient carrier in drug delivery systems. X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FT-IR), and nitrogen adsorption-desorption isotherms were used to characterize the three samples: pure MCM-41, Fe3O4/MCM-41, & CUR@Fe3O4/MCM-41. Adsorption processes tests were carried out to determine the impact of various variables on the CUR load efficiency. These variables were the carrier dosage, pH, contact time, and initial CUR concentration. The maximal drug loading efficiencies (DL %) were 15.78 % and 22.98 %, respectively. According to the data, The Freundlich isotherm had a stronger correlation coefficient R2= 0.999 for MCM-41, while the Langmuir isotherm had a greater R2 of 0.9666 for Fe3O4/MCM-41. A pseudo-second-order kinetic model fits well with R2=0.9827 for MCM-41 and 0.9994 for Fe3O4/MCM-41. Phosphate Buffer Solution (PBS) with a pH of 7.4 was utilized to study CUR release behavior. According to the research, the maximum release for MCM-41 and Fe3O4/MCM-41 might be 74.1 % and 25.19 % after 72 h, respectively. Various kinetic release models were used, including First-order, Korsmeyer-Peppas, Hixson and Crowell, Higuchi, and Weibull. After 72h, the drug release data were fit using a Weibull kinetic model with an R2 of 0.944 and 0.764 for MCM-41 and Fe3O4/MCM-41, respectively.https://etj.uotechnology.edu.iq/article_173481_fc7310b390635480197a7cca453cc026.pdfcurcumindrug delivery systemfe3o4/mcm-41kinetic adsorptionloading and releasemagnetic |
| spellingShingle | Nidhal Atiyah Mohammed Atiya Talib Albayati Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System Engineering and Technology Journal curcumin drug delivery system fe3o4/mcm-41 kinetic adsorption loading and release magnetic |
| title | Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System |
| title_full | Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System |
| title_fullStr | Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System |
| title_full_unstemmed | Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System |
| title_short | Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System |
| title_sort | curcumin loaded onto magnetic mesoporous material mcm 41 for controlled and released in drug delivery system |
| topic | curcumin drug delivery system fe3o4/mcm-41 kinetic adsorption loading and release magnetic |
| url | https://etj.uotechnology.edu.iq/article_173481_fc7310b390635480197a7cca453cc026.pdf |
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