Nuclear Activation Function 2 Estrogen Receptor α Attenuates Arterial and Renal Alterations Due to Aging and Hypertension in Female Mice

Nuclear Activation Function 2 Estrogen Receptor α Attenuates Arterial and Renal Alterations Due to Aging and Hypertension in Female Mice

Background The cardiovascular protective effects of estrogens in premenopausal women depend mainly on estrogen receptor α (ERα). ERα activates nuclear gene transcription regulation and membrane‐initiated signaling. The latter plays a key role in estrogen‐dependent activation of endothelial NO syntha...

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Bibliographic Details
Main Authors: Emmanuel Guivarc'h, Julie Favre, Anne‐Laure Guihot, Emilie Vessières, Linda Grimaud, Coralyne Proux, Jordan Rivron, Agnès Barbelivien, Céline Fassot, Marie Briet, Françoise Lenfant, Coralie Fontaine, Laurent Loufrani, Jean‐François Arnal, Daniel Henrion
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aging
endothelium
estrogen
hypertension
kidney
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.013895

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