Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase
For developmental processes, we know most of the gene networks controlling specific cell responses. We still have to determine how these networks cooperate and how signals become integrated. The JNK pathway is one of the key elements modulating cellular responses during development. Yet, we still kn...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12205 |
| _version_ | 1797510048185843712 |
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| author | Katerina Karkali Enrique Martin-Blanco |
| author_facet | Katerina Karkali Enrique Martin-Blanco |
| author_sort | Katerina Karkali |
| collection | DOAJ |
| description | For developmental processes, we know most of the gene networks controlling specific cell responses. We still have to determine how these networks cooperate and how signals become integrated. The JNK pathway is one of the key elements modulating cellular responses during development. Yet, we still know little about how the core components of the pathway interact with additional regulators or how this network modulates cellular responses in the whole organism in homeostasis or during tissue morphogenesis. We have performed a promoter analysis, searching for potential regulatory sequences of <i>puckered (puc)</i> and identified different specific enhancers directing gene expression in different tissues and at different developmental times. Remarkably, some of these domains respond to the JNK activity, but not all. Altogether, these analyses show that <i>puc</i> expression regulation is very complex and that JNK activities participate in non-previously known processes during the development of <i>Drosophila</i>. |
| first_indexed | 2024-03-10T05:26:23Z |
| format | Article |
| id | doaj.art-3022ff5094b54c4aaee2b447191d2107 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:26:23Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3022ff5094b54c4aaee2b447191d21072023-11-22T23:38:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221220510.3390/ijms222212205Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK PhosphataseKaterina Karkali0Enrique Martin-Blanco1Instituto de Biología Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, SpainInstituto de Biología Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, SpainFor developmental processes, we know most of the gene networks controlling specific cell responses. We still have to determine how these networks cooperate and how signals become integrated. The JNK pathway is one of the key elements modulating cellular responses during development. Yet, we still know little about how the core components of the pathway interact with additional regulators or how this network modulates cellular responses in the whole organism in homeostasis or during tissue morphogenesis. We have performed a promoter analysis, searching for potential regulatory sequences of <i>puckered (puc)</i> and identified different specific enhancers directing gene expression in different tissues and at different developmental times. Remarkably, some of these domains respond to the JNK activity, but not all. Altogether, these analyses show that <i>puc</i> expression regulation is very complex and that JNK activities participate in non-previously known processes during the development of <i>Drosophila</i>.https://www.mdpi.com/1422-0067/22/22/12205JNK<i>Drosophila</i>dual specificity phosphatasegene expression |
| spellingShingle | Katerina Karkali Enrique Martin-Blanco Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase International Journal of Molecular Sciences JNK <i>Drosophila</i> dual specificity phosphatase gene expression |
| title | Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase |
| title_full | Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase |
| title_fullStr | Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase |
| title_full_unstemmed | Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase |
| title_short | Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase |
| title_sort | dissection of the regulatory elements of the complex expression pattern of puckered a dual specificity jnk phosphatase |
| topic | JNK <i>Drosophila</i> dual specificity phosphatase gene expression |
| url | https://www.mdpi.com/1422-0067/22/22/12205 |
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