Task-residual effective connectivity of motor network in transient ischemic attack
Abstract Transient ischemic attack (TIA) is a temporary episode of neurological dysfunction that results from focal brain ischemia. Although TIA symptoms are quickly resolved, patients with TIA have a high risk of stroke and persistent impairments in multiple domains of cognitive and motor functions...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05212-3 |
| _version_ | 1797557131490099200 |
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| author | Truc Chu Seonjin Lee Il-Young Jung Youngkyu Song Hyun-Ah Kim Jong Wook Shin Sungho Tak |
| author_facet | Truc Chu Seonjin Lee Il-Young Jung Youngkyu Song Hyun-Ah Kim Jong Wook Shin Sungho Tak |
| author_sort | Truc Chu |
| collection | DOAJ |
| description | Abstract Transient ischemic attack (TIA) is a temporary episode of neurological dysfunction that results from focal brain ischemia. Although TIA symptoms are quickly resolved, patients with TIA have a high risk of stroke and persistent impairments in multiple domains of cognitive and motor functions. In this study, using spectral dynamic causal modeling, we investigate the changes in task-residual effective connectivity of patients with TIA during fist-closing movements. 28 healthy participants and 15 age-matched patients with TIA undergo functional magnetic resonance imaging at 7T. Here we show that during visually cued motor movement, patients with TIA have significantly higher effective connectivity toward the ipsilateral primary motor cortex and lower connectivity to the supplementary motor area than healthy controls. Our results imply that TIA patients have aberrant connections among motor regions, and these changes may reflect the decreased efficiency of primary motor function and disrupted control of voluntary movement in patients with TIA. |
| first_indexed | 2024-03-10T17:12:58Z |
| format | Article |
| id | doaj.art-3024255906da4501b75a30643325ace9 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-10T17:12:58Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-3024255906da4501b75a30643325ace92023-11-20T10:34:50ZengNature PortfolioCommunications Biology2399-36422023-08-016111110.1038/s42003-023-05212-3Task-residual effective connectivity of motor network in transient ischemic attackTruc Chu0Seonjin Lee1Il-Young Jung2Youngkyu Song3Hyun-Ah Kim4Jong Wook Shin5Sungho Tak6Research Center for Bioconvergence Analysis, Korea Basic Science InstituteResearch Center for Bioconvergence Analysis, Korea Basic Science InstituteDepartment of Rehabilitation Medicine, Chungnam National University Sejong HospitalBio-Chemical Analysis Team, Korea Basic Science InstituteDepartment of Rehabilitation Medicine, Chungnam National University HospitalDepartment of Neurology, Chungnam National University Sejong HospitalResearch Center for Bioconvergence Analysis, Korea Basic Science InstituteAbstract Transient ischemic attack (TIA) is a temporary episode of neurological dysfunction that results from focal brain ischemia. Although TIA symptoms are quickly resolved, patients with TIA have a high risk of stroke and persistent impairments in multiple domains of cognitive and motor functions. In this study, using spectral dynamic causal modeling, we investigate the changes in task-residual effective connectivity of patients with TIA during fist-closing movements. 28 healthy participants and 15 age-matched patients with TIA undergo functional magnetic resonance imaging at 7T. Here we show that during visually cued motor movement, patients with TIA have significantly higher effective connectivity toward the ipsilateral primary motor cortex and lower connectivity to the supplementary motor area than healthy controls. Our results imply that TIA patients have aberrant connections among motor regions, and these changes may reflect the decreased efficiency of primary motor function and disrupted control of voluntary movement in patients with TIA.https://doi.org/10.1038/s42003-023-05212-3 |
| spellingShingle | Truc Chu Seonjin Lee Il-Young Jung Youngkyu Song Hyun-Ah Kim Jong Wook Shin Sungho Tak Task-residual effective connectivity of motor network in transient ischemic attack Communications Biology |
| title | Task-residual effective connectivity of motor network in transient ischemic attack |
| title_full | Task-residual effective connectivity of motor network in transient ischemic attack |
| title_fullStr | Task-residual effective connectivity of motor network in transient ischemic attack |
| title_full_unstemmed | Task-residual effective connectivity of motor network in transient ischemic attack |
| title_short | Task-residual effective connectivity of motor network in transient ischemic attack |
| title_sort | task residual effective connectivity of motor network in transient ischemic attack |
| url | https://doi.org/10.1038/s42003-023-05212-3 |
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