Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage—Preliminary Study
(1) Background: The aim of this study was to assess the concentrations of selected elements in female patients with cancer of the reproductive organs, taking into account the stage of treatment. (2) Methods: The study sample consisted of 51 patients with advanced endometrial cancer and ovarian cance...
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/12/2368 |
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| author | Sylwia Wieder-Huszla Anita Chudecka-Głaz Aneta Cymbaluk-Płoska Beata Karakiewicz Mateusz Bosiacki Dariusz Chlubek Anna Jurczak |
| author_facet | Sylwia Wieder-Huszla Anita Chudecka-Głaz Aneta Cymbaluk-Płoska Beata Karakiewicz Mateusz Bosiacki Dariusz Chlubek Anna Jurczak |
| author_sort | Sylwia Wieder-Huszla |
| collection | DOAJ |
| description | (1) Background: The aim of this study was to assess the concentrations of selected elements in female patients with cancer of the reproductive organs, taking into account the stage of treatment. (2) Methods: The study sample consisted of 51 patients with advanced endometrial cancer and ovarian cancer, undergoing chemotherapy. The median age of the studied patients with endometrial cancer was 66.0 years (IQR: from 60.75 to 70.25), and with ovarian cancer―60.0 years (IQR: from 49.0 to 64.0). Each of the qualified women, after consent to participate in the study, had her blood drawn several times (before surgery, the first course of chemotherapy, the third course of chemotherapy, and the sixth course of chemotherapy) in order to determine serum levels of macro- and micronutrients (Na, Mg, Ca, Zn, P, Cu, Fe, Cd, Ni, and Sr). (3) Results: In the study group of patients with cancer of the reproductive tract, the concentrations of iron (<0.001), magnesium (0.038), sodium (0.014), and nickel (0.037) varied significantly over the course of the study. The analysis showed that the interaction between the stage of chemotherapy and the type of cancer had an effect on the concentrations of magnesium and cadmium (<i>p</i> < 0.05). (4) Conclusions: In the studied group of patients with ovarian and endometrial cancer, the applied chemotherapy significantly changed the concentrations of Fe, Na, and Ni, regardless of the type of tumor. Changes in Mg and Cd concentrations resulted from the interaction between the stage of chemotherapy and the type of cancer. The results of serum concentrations of selected elements in women with cancer of the reproductive organs may help understand the physiological changes resulting from the applied chemotherapy. |
| first_indexed | 2024-03-09T22:51:06Z |
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| id | doaj.art-302588b631b54895bfc4b386c00aec49 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:51:06Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-302588b631b54895bfc4b386c00aec492023-11-23T18:19:50ZengMDPI AGNutrients2072-66432022-06-011412236810.3390/nu14122368Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage—Preliminary StudySylwia Wieder-Huszla0Anita Chudecka-Głaz1Aneta Cymbaluk-Płoska2Beata Karakiewicz3Mateusz Bosiacki4Dariusz Chlubek5Anna Jurczak6Department of Clinical Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Social Medicine and Public Health, Pomeranian Medical University in Szczecin, 71-210 Szczecin, PolandDepartment of Functional Diagnostics and Physical Medicine, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Clinical Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland(1) Background: The aim of this study was to assess the concentrations of selected elements in female patients with cancer of the reproductive organs, taking into account the stage of treatment. (2) Methods: The study sample consisted of 51 patients with advanced endometrial cancer and ovarian cancer, undergoing chemotherapy. The median age of the studied patients with endometrial cancer was 66.0 years (IQR: from 60.75 to 70.25), and with ovarian cancer―60.0 years (IQR: from 49.0 to 64.0). Each of the qualified women, after consent to participate in the study, had her blood drawn several times (before surgery, the first course of chemotherapy, the third course of chemotherapy, and the sixth course of chemotherapy) in order to determine serum levels of macro- and micronutrients (Na, Mg, Ca, Zn, P, Cu, Fe, Cd, Ni, and Sr). (3) Results: In the study group of patients with cancer of the reproductive tract, the concentrations of iron (<0.001), magnesium (0.038), sodium (0.014), and nickel (0.037) varied significantly over the course of the study. The analysis showed that the interaction between the stage of chemotherapy and the type of cancer had an effect on the concentrations of magnesium and cadmium (<i>p</i> < 0.05). (4) Conclusions: In the studied group of patients with ovarian and endometrial cancer, the applied chemotherapy significantly changed the concentrations of Fe, Na, and Ni, regardless of the type of tumor. Changes in Mg and Cd concentrations resulted from the interaction between the stage of chemotherapy and the type of cancer. The results of serum concentrations of selected elements in women with cancer of the reproductive organs may help understand the physiological changes resulting from the applied chemotherapy.https://www.mdpi.com/2072-6643/14/12/2368biochemical parametersovarian cancerendometrial cancerchemotherapywomen’s health |
| spellingShingle | Sylwia Wieder-Huszla Anita Chudecka-Głaz Aneta Cymbaluk-Płoska Beata Karakiewicz Mateusz Bosiacki Dariusz Chlubek Anna Jurczak Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage—Preliminary Study Nutrients biochemical parameters ovarian cancer endometrial cancer chemotherapy women’s health |
| title | Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage—Preliminary Study |
| title_full | Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage—Preliminary Study |
| title_fullStr | Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage—Preliminary Study |
| title_full_unstemmed | Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage—Preliminary Study |
| title_short | Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage—Preliminary Study |
| title_sort | evaluation of the concentration of selected elements in patients with cancer of the reproductive organs with respect to treatment stage preliminary study |
| topic | biochemical parameters ovarian cancer endometrial cancer chemotherapy women’s health |
| url | https://www.mdpi.com/2072-6643/14/12/2368 |
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