miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling

miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling

Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. MicroRNAs (miRNAs) are known to be important regulators of GC. This study aims to investigate the role of miRNA (miR)-497 in GC. We demonstrated that the expression of miR-497 was downregulated in human GC tissues. A...

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Bibliographic Details
Main Authors: Lihui Zhang, Liwen Yao, Wei Zhou, Jinping Tian, Banlai Ruan, Zihua Lu, Yunchao Deng, Qing Li, Zhi Zeng, Dongmei Yang, Renduo Shang, Ming Xu, Mengjiao Zhang, Du Cheng, Yanning Yang, Qianshan Ding, Honggang Yu
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
gastric cancer
miR-497
CDC42
tumorigenesis
focal adhesion kinase
paxillin
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001931

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http://www.sciencedirect.com/science/article/pii/S2162253121001931

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