Features of Nitration of Aromatic Aldehydes with the Difluoromethoxy Group
Nitration of aromatic aldehydes with difluoromethoxy group results in the partial ipso-substitution of the aldehyde group if difluoromethoxy group is located in the para-position to the aldehyde group. The presence of a chlorine atom in the meta-position to the aldehyde group increases the contribut...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
National University of Pharmacy (Kharkiv, Ukraine)
2023-11-01
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| Series: | Журнал органічної та фармацевтичної хімії |
| Subjects: | |
| Online Access: | https://ophcj.nuph.edu.ua/article/view/285469 |
| Summary: | Nitration of aromatic aldehydes with difluoromethoxy group results in the partial ipso-substitution of the aldehyde group if difluoromethoxy group is located in the para-position to the aldehyde group. The presence of a chlorine atom in the meta-position to the aldehyde group increases the contribution of the ipso-substitution, while the presence of a chlorine atom in the ortho-position to the aldehyde group reduces it. The presence of strong donors (alkoxy groups) in the molecule eliminates the contribution of the ipso-substitution. |
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| ISSN: | 2308-8303 2518-1548 |