Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients
<p>Abstract</p> <p>Many different methods were developed to detect commonly known mutations and to screen new mutations of the epidermal growth factor receptor in non-small cell lung cancer patients. Some of these methods are so sensitive as to be able to detect even one epidermal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2012-12-01
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| Series: | Multidisciplinary Respiratory Medicine |
| Subjects: | |
| Online Access: | http://www.mrmjournal.com/content/7/1/52 |
| _version_ | 1797281867351719936 |
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| author | Obradovic Jasmina Jurisic Vladimir |
| author_facet | Obradovic Jasmina Jurisic Vladimir |
| author_sort | Obradovic Jasmina |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Many different methods were developed to detect commonly known mutations and to screen new mutations of the epidermal growth factor receptor in non-small cell lung cancer patients. Some of these methods are so sensitive as to be able to detect even one epidermal growth factor receptor mutant tumor cell among up to 1000–2000 normal cells. We have considered current methods chronologically reported to detect mutations in epidermal growth factor receptor in patients with non-small cell lung cancer. We also gave a short preview of their significance for routine clinical works. A Pub Med literature search was performed in order to demonstrate what methods are mostly used in mutation detection and to show their distribution through the last 10 years.</p> |
| first_indexed | 2024-03-07T17:03:38Z |
| format | Article |
| id | doaj.art-30284fb49df54d36a5026ab3ef3b460e |
| institution | Directory Open Access Journal |
| issn | 2049-6958 |
| language | English |
| last_indexed | 2024-03-07T17:03:38Z |
| publishDate | 2012-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Multidisciplinary Respiratory Medicine |
| spelling | doaj.art-30284fb49df54d36a5026ab3ef3b460e2024-03-03T02:54:28ZengPAGEPress PublicationsMultidisciplinary Respiratory Medicine2049-69582012-12-01715210.1186/2049-6958-7-52Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patientsObradovic JasminaJurisic Vladimir<p>Abstract</p> <p>Many different methods were developed to detect commonly known mutations and to screen new mutations of the epidermal growth factor receptor in non-small cell lung cancer patients. Some of these methods are so sensitive as to be able to detect even one epidermal growth factor receptor mutant tumor cell among up to 1000–2000 normal cells. We have considered current methods chronologically reported to detect mutations in epidermal growth factor receptor in patients with non-small cell lung cancer. We also gave a short preview of their significance for routine clinical works. A Pub Med literature search was performed in order to demonstrate what methods are mostly used in mutation detection and to show their distribution through the last 10 years.</p>http://www.mrmjournal.com/content/7/1/52EGFRMethodsMutationsNSCLC |
| spellingShingle | Obradovic Jasmina Jurisic Vladimir Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients Multidisciplinary Respiratory Medicine EGFR Methods Mutations NSCLC |
| title | Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients |
| title_full | Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients |
| title_fullStr | Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients |
| title_full_unstemmed | Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients |
| title_short | Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients |
| title_sort | evaluation of current methods to detect the mutations of epidermal growth factor receptor in non small cell lung cancer patients |
| topic | EGFR Methods Mutations NSCLC |
| url | http://www.mrmjournal.com/content/7/1/52 |
| work_keys_str_mv | AT obradovicjasmina evaluationofcurrentmethodstodetectthemutationsofepidermalgrowthfactorreceptorinnonsmallcelllungcancerpatients AT jurisicvladimir evaluationofcurrentmethodstodetectthemutationsofepidermalgrowthfactorreceptorinnonsmallcelllungcancerpatients |