Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting
Cancer is a major threat to the health of humans. Recently, various natural products including curcumin (CCM) have attracted enormous interest for efficacious cancer therapy. However, natural therapeutic agents still encounter certain challenges such as rapid clearance, low bioavailability, and poor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/12/2614 |
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| author | Shengli Wan Yuesong Wu Qingze Fan Gang Yang Haiyang Hu Singkome Tima Sawitree Chiampanichayakul Songyot Anuchapreeda Jianming Wu |
| author_facet | Shengli Wan Yuesong Wu Qingze Fan Gang Yang Haiyang Hu Singkome Tima Sawitree Chiampanichayakul Songyot Anuchapreeda Jianming Wu |
| author_sort | Shengli Wan |
| collection | DOAJ |
| description | Cancer is a major threat to the health of humans. Recently, various natural products including curcumin (CCM) have attracted enormous interest for efficacious cancer therapy. However, natural therapeutic agents still encounter certain challenges such as rapid clearance, low bioavailability, and poor tumor targeting. Recently, the platelet membrane (PM) camouflaged nanoparticle has provided a promising solution for cancer targeting therapy. Nevertheless, only limited efforts have been dedicated to systematically explore the mechanism of affinity between PM bioinspired nanoparticles and various tumor cells. Herein, a CCM-encapsulated platelet membrane biomimetic lipid vesicle (CCM@PL) with a size of 163.2 nm, zeta potential of −31.8 mV and encapsulation efficiency of 93.62% was developed. The values of the area under the concentration-time curve and mean residence time for CCM@PL were 3.08 times and 3.04 times those of CCM, respectively. Furthermore, this PM biomimetic carrier showed an excellent affinity against Huh-7, SK-OV-3 and MDA-MB-231 cell lines due to the biomolecular interaction between P-selectin on the PM and tumoral CD44 receptors. In addition, CCM@PL displayed enhanced cytotoxicity compared with free CCM and the synthetic formulation. Overall, our results suggest that this developed PM biomimetic lipid nanovector has great potential for targeted cancer treatment and natural components delivery. |
| first_indexed | 2024-03-09T15:58:10Z |
| format | Article |
| id | doaj.art-3028e6ada614476cb0c7299d0c16243d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:10Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3028e6ada614476cb0c7299d0c16243d2023-11-24T17:18:59ZengMDPI AGPharmaceutics1999-49232022-11-011412261410.3390/pharmaceutics14122614Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin TargetingShengli Wan0Yuesong Wu1Qingze Fan2Gang Yang3Haiyang Hu4Singkome Tima5Sawitree Chiampanichayakul6Songyot Anuchapreeda7Jianming Wu8Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, ThailandSchool of Pharmacy, Southwest Medical University, Luzhou 646000, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou 646000, ChinaDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, ThailandSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaCancer is a major threat to the health of humans. Recently, various natural products including curcumin (CCM) have attracted enormous interest for efficacious cancer therapy. However, natural therapeutic agents still encounter certain challenges such as rapid clearance, low bioavailability, and poor tumor targeting. Recently, the platelet membrane (PM) camouflaged nanoparticle has provided a promising solution for cancer targeting therapy. Nevertheless, only limited efforts have been dedicated to systematically explore the mechanism of affinity between PM bioinspired nanoparticles and various tumor cells. Herein, a CCM-encapsulated platelet membrane biomimetic lipid vesicle (CCM@PL) with a size of 163.2 nm, zeta potential of −31.8 mV and encapsulation efficiency of 93.62% was developed. The values of the area under the concentration-time curve and mean residence time for CCM@PL were 3.08 times and 3.04 times those of CCM, respectively. Furthermore, this PM biomimetic carrier showed an excellent affinity against Huh-7, SK-OV-3 and MDA-MB-231 cell lines due to the biomolecular interaction between P-selectin on the PM and tumoral CD44 receptors. In addition, CCM@PL displayed enhanced cytotoxicity compared with free CCM and the synthetic formulation. Overall, our results suggest that this developed PM biomimetic lipid nanovector has great potential for targeted cancer treatment and natural components delivery.https://www.mdpi.com/1999-4923/14/12/2614platelet membranelipid nanovectortargeted cancer therapycurcumin |
| spellingShingle | Shengli Wan Yuesong Wu Qingze Fan Gang Yang Haiyang Hu Singkome Tima Sawitree Chiampanichayakul Songyot Anuchapreeda Jianming Wu Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting Pharmaceutics platelet membrane lipid nanovector targeted cancer therapy curcumin |
| title | Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting |
| title_full | Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting |
| title_fullStr | Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting |
| title_full_unstemmed | Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting |
| title_short | Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting |
| title_sort | bioinspired platelet like nanovector for enhancing cancer therapy via p selectin targeting |
| topic | platelet membrane lipid nanovector targeted cancer therapy curcumin |
| url | https://www.mdpi.com/1999-4923/14/12/2614 |
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