Effects of <i>Pueraria candollei</i> var <i>mirifica</i> (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain
The effects of the phytoestrogen-enriched plant <i>Pueraria mirifica</i> (PM) extract on ovari-ectomy (OVX)-induced cognitive impairment and hippocampal oxidative stress in mice were investigated. Daily treatment with PM and 17β-estradiol (E2) significantly elevated cognitive behavior as...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/11/3442 |
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| author | Yaowared Chulikhit Wichitsak Sukhano Supawadee Daodee Waraporn Putalun Rakvajee Wongpradit Charinya Khamphukdee Kaoru Umehara Hiroshi Noguchi Kinzo Matsumoto Orawan Monthakantirat |
| author_facet | Yaowared Chulikhit Wichitsak Sukhano Supawadee Daodee Waraporn Putalun Rakvajee Wongpradit Charinya Khamphukdee Kaoru Umehara Hiroshi Noguchi Kinzo Matsumoto Orawan Monthakantirat |
| author_sort | Yaowared Chulikhit |
| collection | DOAJ |
| description | The effects of the phytoestrogen-enriched plant <i>Pueraria mirifica</i> (PM) extract on ovari-ectomy (OVX)-induced cognitive impairment and hippocampal oxidative stress in mice were investigated. Daily treatment with PM and 17β-estradiol (E2) significantly elevated cognitive behavior as evaluated by using the Y maze test, the novel object recognition test (NORT), and the Morris water maze test (MWM), attenuated atrophic changes in the uterus and decreased serum 17β-estradiol levels. The treatments significantly ameliorated ovariectomy-induced oxidative stress in the hippocampus and serum by a decrease in malondialdehyde (MDA), an enhancement of superoxide dismutase, and catalase activity, including significantly down-regulated expression of IL-1β, IL-6 and TNF-α proinflammatory cytokines, while up-regulating expression of PI3K. The present results suggest that PM extract suppresses oxidative brain damage and dysfunctions in the hippocampal antioxidant system, including the neuroinflammatory system in OVX animals, thereby preventing OVX-induced cognitive impairment. The present results indicate that PM exerts beneficial effects on cognitive deficits for which menopause/ovariectomy have been implicated as risk factors. |
| first_indexed | 2024-03-10T10:40:48Z |
| format | Article |
| id | doaj.art-3029c13819434797a64b62aab1d63e0e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:40:48Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3029c13819434797a64b62aab1d63e0e2023-11-21T22:58:00ZengMDPI AGMolecules1420-30492021-06-012611344210.3390/molecules26113442Effects of <i>Pueraria candollei</i> var <i>mirifica</i> (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse BrainYaowared Chulikhit0Wichitsak Sukhano1Supawadee Daodee2Waraporn Putalun3Rakvajee Wongpradit4Charinya Khamphukdee5Kaoru Umehara6Hiroshi Noguchi7Kinzo Matsumoto8Orawan Monthakantirat9Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Pharmacognosy, School of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Shi-zuoka-shi, Shizuoka 422-8526, JapanDepartment of Pharmacognosy, School of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Shi-zuoka-shi, Shizuoka 422-8526, JapanDivision of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDivision of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandThe effects of the phytoestrogen-enriched plant <i>Pueraria mirifica</i> (PM) extract on ovari-ectomy (OVX)-induced cognitive impairment and hippocampal oxidative stress in mice were investigated. Daily treatment with PM and 17β-estradiol (E2) significantly elevated cognitive behavior as evaluated by using the Y maze test, the novel object recognition test (NORT), and the Morris water maze test (MWM), attenuated atrophic changes in the uterus and decreased serum 17β-estradiol levels. The treatments significantly ameliorated ovariectomy-induced oxidative stress in the hippocampus and serum by a decrease in malondialdehyde (MDA), an enhancement of superoxide dismutase, and catalase activity, including significantly down-regulated expression of IL-1β, IL-6 and TNF-α proinflammatory cytokines, while up-regulating expression of PI3K. The present results suggest that PM extract suppresses oxidative brain damage and dysfunctions in the hippocampal antioxidant system, including the neuroinflammatory system in OVX animals, thereby preventing OVX-induced cognitive impairment. The present results indicate that PM exerts beneficial effects on cognitive deficits for which menopause/ovariectomy have been implicated as risk factors.https://www.mdpi.com/1420-3049/26/11/3442<i>Pueraria candollei</i> var. <i>mirifica</i>ovariectomycognitive dysfunctionoxidative damageneuroinflammation |
| spellingShingle | Yaowared Chulikhit Wichitsak Sukhano Supawadee Daodee Waraporn Putalun Rakvajee Wongpradit Charinya Khamphukdee Kaoru Umehara Hiroshi Noguchi Kinzo Matsumoto Orawan Monthakantirat Effects of <i>Pueraria candollei</i> var <i>mirifica</i> (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain Molecules <i>Pueraria candollei</i> var. <i>mirifica</i> ovariectomy cognitive dysfunction oxidative damage neuroinflammation |
| title | Effects of <i>Pueraria candollei</i> var <i>mirifica</i> (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain |
| title_full | Effects of <i>Pueraria candollei</i> var <i>mirifica</i> (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain |
| title_fullStr | Effects of <i>Pueraria candollei</i> var <i>mirifica</i> (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain |
| title_full_unstemmed | Effects of <i>Pueraria candollei</i> var <i>mirifica</i> (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain |
| title_short | Effects of <i>Pueraria candollei</i> var <i>mirifica</i> (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain |
| title_sort | effects of i pueraria candollei i var i mirifica i airy shaw and suvat niyomdham on ovariectomy induced cognitive impairment and oxidative stress in the mouse brain |
| topic | <i>Pueraria candollei</i> var. <i>mirifica</i> ovariectomy cognitive dysfunction oxidative damage neuroinflammation |
| url | https://www.mdpi.com/1420-3049/26/11/3442 |
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