Liquid Biopsies for Molecular Biology-Based Radiotherapy
Molecular alterations drive cancer initiation and evolution during development and in response to therapy. Radiotherapy is one of the most commonly employed cancer treatment modalities, but radiobiologic approaches for personalizing therapy based on tumor biology and individual risks remain to be de...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/20/11267 |
| _version_ | 1797514327131947008 |
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| author | Erik S. Blomain Everett J. Moding |
| author_facet | Erik S. Blomain Everett J. Moding |
| author_sort | Erik S. Blomain |
| collection | DOAJ |
| description | Molecular alterations drive cancer initiation and evolution during development and in response to therapy. Radiotherapy is one of the most commonly employed cancer treatment modalities, but radiobiologic approaches for personalizing therapy based on tumor biology and individual risks remain to be defined. In recent years, analysis of circulating nucleic acids has emerged as a non-invasive approach to leverage tumor molecular abnormalities as biomarkers of prognosis and treatment response. Here, we evaluate the roles of circulating tumor DNA and related analyses as powerful tools for precision radiotherapy. We highlight emerging work advancing liquid biopsies beyond biomarker studies into translational research investigating tumor clonal evolution and acquired resistance. |
| first_indexed | 2024-03-10T06:29:36Z |
| format | Article |
| id | doaj.art-3029ccb37765426fb4db897c88daab1b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:29:36Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3029ccb37765426fb4db897c88daab1b2023-11-22T18:36:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122201126710.3390/ijms222011267Liquid Biopsies for Molecular Biology-Based RadiotherapyErik S. Blomain0Everett J. Moding1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USAMolecular alterations drive cancer initiation and evolution during development and in response to therapy. Radiotherapy is one of the most commonly employed cancer treatment modalities, but radiobiologic approaches for personalizing therapy based on tumor biology and individual risks remain to be defined. In recent years, analysis of circulating nucleic acids has emerged as a non-invasive approach to leverage tumor molecular abnormalities as biomarkers of prognosis and treatment response. Here, we evaluate the roles of circulating tumor DNA and related analyses as powerful tools for precision radiotherapy. We highlight emerging work advancing liquid biopsies beyond biomarker studies into translational research investigating tumor clonal evolution and acquired resistance.https://www.mdpi.com/1422-0067/22/20/11267circulating tumor DNAliquid biopsiesradiation biologybiomarkersprecision oncologytumor evolution |
| spellingShingle | Erik S. Blomain Everett J. Moding Liquid Biopsies for Molecular Biology-Based Radiotherapy International Journal of Molecular Sciences circulating tumor DNA liquid biopsies radiation biology biomarkers precision oncology tumor evolution |
| title | Liquid Biopsies for Molecular Biology-Based Radiotherapy |
| title_full | Liquid Biopsies for Molecular Biology-Based Radiotherapy |
| title_fullStr | Liquid Biopsies for Molecular Biology-Based Radiotherapy |
| title_full_unstemmed | Liquid Biopsies for Molecular Biology-Based Radiotherapy |
| title_short | Liquid Biopsies for Molecular Biology-Based Radiotherapy |
| title_sort | liquid biopsies for molecular biology based radiotherapy |
| topic | circulating tumor DNA liquid biopsies radiation biology biomarkers precision oncology tumor evolution |
| url | https://www.mdpi.com/1422-0067/22/20/11267 |
| work_keys_str_mv | AT eriksblomain liquidbiopsiesformolecularbiologybasedradiotherapy AT everettjmoding liquidbiopsiesformolecularbiologybasedradiotherapy |