Lung inflammation perturbation by engineered nanoparticles
In recent years, the unique and diverse physicochemical properties of nanoparticles have brought about their wide use in many fields; however, it is necessary to better understand the possible human health risks caused by their release in the environment. Although the adverse health effects of nanop...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1199230/full |
| _version_ | 1797820501670756352 |
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| author | Xiaofei Zhou Weitao Jin Jingjun Ma |
| author_facet | Xiaofei Zhou Weitao Jin Jingjun Ma |
| author_sort | Xiaofei Zhou |
| collection | DOAJ |
| description | In recent years, the unique and diverse physicochemical properties of nanoparticles have brought about their wide use in many fields; however, it is necessary to better understand the possible human health risks caused by their release in the environment. Although the adverse health effects of nanoparticles have been proposed and are still being clarified, their effects on lung health have not been fully studied. In this review, we focus on the latest research progress on the pulmonary toxic effects of nanoparticles, and we summarized their disturbance of the pulmonary inflammatory response. First, the activation of lung inflammation by nanoparticles was reviewed. Second, we discussed how further exposure to nanoparticles aggravated the ongoing lung inflammation. Third, we summarized the inhibition of the ongoing lung inflammation by nanoparticles loaded with anti-inflammatory drugs. Forth, we introduced how the physicochemical properties of nanoparticles affect the related pulmonary inflammatory disturbance. Finally, we discussed the main gaps in current research and the challenges and countermeasures in future research. |
| first_indexed | 2024-03-13T09:39:19Z |
| format | Article |
| id | doaj.art-302a8e87823e456fb112c8c82eab016d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-13T09:39:19Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-302a8e87823e456fb112c8c82eab016d2023-05-25T04:29:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-05-011110.3389/fbioe.2023.11992301199230Lung inflammation perturbation by engineered nanoparticlesXiaofei ZhouWeitao JinJingjun MaIn recent years, the unique and diverse physicochemical properties of nanoparticles have brought about their wide use in many fields; however, it is necessary to better understand the possible human health risks caused by their release in the environment. Although the adverse health effects of nanoparticles have been proposed and are still being clarified, their effects on lung health have not been fully studied. In this review, we focus on the latest research progress on the pulmonary toxic effects of nanoparticles, and we summarized their disturbance of the pulmonary inflammatory response. First, the activation of lung inflammation by nanoparticles was reviewed. Second, we discussed how further exposure to nanoparticles aggravated the ongoing lung inflammation. Third, we summarized the inhibition of the ongoing lung inflammation by nanoparticles loaded with anti-inflammatory drugs. Forth, we introduced how the physicochemical properties of nanoparticles affect the related pulmonary inflammatory disturbance. Finally, we discussed the main gaps in current research and the challenges and countermeasures in future research.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1199230/fullnanoparticleslung inflammationmechanismsphysicochemical propertiesbiosafety evaluation |
| spellingShingle | Xiaofei Zhou Weitao Jin Jingjun Ma Lung inflammation perturbation by engineered nanoparticles Frontiers in Bioengineering and Biotechnology nanoparticles lung inflammation mechanisms physicochemical properties biosafety evaluation |
| title | Lung inflammation perturbation by engineered nanoparticles |
| title_full | Lung inflammation perturbation by engineered nanoparticles |
| title_fullStr | Lung inflammation perturbation by engineered nanoparticles |
| title_full_unstemmed | Lung inflammation perturbation by engineered nanoparticles |
| title_short | Lung inflammation perturbation by engineered nanoparticles |
| title_sort | lung inflammation perturbation by engineered nanoparticles |
| topic | nanoparticles lung inflammation mechanisms physicochemical properties biosafety evaluation |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1199230/full |
| work_keys_str_mv | AT xiaofeizhou lunginflammationperturbationbyengineerednanoparticles AT weitaojin lunginflammationperturbationbyengineerednanoparticles AT jingjunma lunginflammationperturbationbyengineerednanoparticles |