Ateroprotective effects of Plinia cauliflora in. New Zealand rabbits: beyond the lipid-lowering effect
Introduction:Plinia cauliflora [Mart.] Kausel (Myrtaceae), popularly known as “jabuticaba,” is a fruit species native to Brazil. Despite extensive widespread usage, its antiatherosclerotic properties' impact remains unknown. Thus, the present study aimed to investigate the cardioprotective effe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1244632/full |
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| author | Ana Paula Cestari Francielly Mourão Gasparotto Cândida Aparecida Leite Kassuya Tauany Milan Ribeiro Lacerda Guilherme Donadel Catia Sari Moura Daniela Boleta Ceranto Ezilda Jacomassi Odair Alberton Salviano Belletini Tramontini Luana Ale Bertoncello Arquimedes Gasparotto Junior Emerson Luiz Botelho Lourenço |
| author_facet | Ana Paula Cestari Francielly Mourão Gasparotto Cândida Aparecida Leite Kassuya Tauany Milan Ribeiro Lacerda Guilherme Donadel Catia Sari Moura Daniela Boleta Ceranto Ezilda Jacomassi Odair Alberton Salviano Belletini Tramontini Luana Ale Bertoncello Arquimedes Gasparotto Junior Emerson Luiz Botelho Lourenço |
| author_sort | Ana Paula Cestari |
| collection | DOAJ |
| description | Introduction:Plinia cauliflora [Mart.] Kausel (Myrtaceae), popularly known as “jabuticaba,” is a fruit species native to Brazil. Despite extensive widespread usage, its antiatherosclerotic properties' impact remains unknown. Thus, the present study aimed to investigate the cardioprotective effects of a preparation obtained from the fruit peels of P. cauliflora (EEPC).Methods: Male New Zealand rabbits received a 1% cholesterol-supplemented diet for 60 days. On the thirtieth day, the animals were divided into five experimental groups and received, once a day, by the oral route, the EEPC (10, 30, and 100 mg/kg), simvastatin (2.5 mg/kg), or vehicle for 30 days. At the end of the experimental period, peripheral blood and arterial branch samples were collected. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), malondialdehyde (MDA), nitrotyrosine (NT), nitrite, interleukin 1 beta (IL-1b), interleukin 6 (IL-6), soluble inter-cellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels were measured. Moreover, the catalase and superoxide dismutase levels were measured on the arterial samples. Histopathological analysis and arterial morphometry were also performed.Results and discussion: The oral administration of ESEG significantly lowered the levels of lipids in rabbits that were fed a CRD diet. This treatment also adjusted the protective system against oxidation in the arteries by decreasing the oxidation of lipids and proteins. Additionally, the levels of IL-1b, IL-6, sICAM-1, and sVCAM-1 in the bloodstream decreased significantly, and this was accompanied by a reduction of atherosclerotic lesions in all branches of the arteries. The findings suggest that EEPC may be a possible option for additional management of atherosclerosis. |
| first_indexed | 2024-03-08T14:37:02Z |
| format | Article |
| id | doaj.art-302a925808bd4bb6b3f27d8e6075bcac |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T14:37:02Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-302a925808bd4bb6b3f27d8e6075bcac2024-01-12T04:31:23ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-01-011510.3389/fphar.2024.12446321244632Ateroprotective effects of Plinia cauliflora in. New Zealand rabbits: beyond the lipid-lowering effectAna Paula Cestari0Francielly Mourão Gasparotto1Cândida Aparecida Leite Kassuya2Tauany Milan Ribeiro Lacerda3Guilherme Donadel4Catia Sari Moura5Daniela Boleta Ceranto6Ezilda Jacomassi7Odair Alberton8Salviano Belletini Tramontini9Luana Ale Bertoncello10Arquimedes Gasparotto Junior11Emerson Luiz Botelho Lourenço12Master’s Degree in Medicinal Plants and Herbal Medicines in Basic Healthcare, Paranaense University, Umuarama, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, BrazilMaster’s Degree in Medicinal Plants and Herbal Medicines in Basic Healthcare, Paranaense University, Umuarama, BrazilMaster’s Degree in Medicinal Plants and Herbal Medicines in Basic Healthcare, Paranaense University, Umuarama, BrazilMaster’s Degree in Medicinal Plants and Herbal Medicines in Basic Healthcare, Paranaense University, Umuarama, BrazilMaster’s Degree in Medicinal Plants and Herbal Medicines in Basic Healthcare, Paranaense University, Umuarama, BrazilMaster’s Degree in Medicinal Plants and Herbal Medicines in Basic Healthcare, Paranaense University, Umuarama, BrazilMaster’s Degree in Medicinal Plants and Herbal Medicines in Basic Healthcare, Paranaense University, Umuarama, BrazilMaster’s Degree in Medicinal Plants and Herbal Medicines in Basic Healthcare, Paranaense University, Umuarama, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, BrazilMaster’s Degree in Medicinal Plants and Herbal Medicines in Basic Healthcare, Paranaense University, Umuarama, BrazilIntroduction:Plinia cauliflora [Mart.] Kausel (Myrtaceae), popularly known as “jabuticaba,” is a fruit species native to Brazil. Despite extensive widespread usage, its antiatherosclerotic properties' impact remains unknown. Thus, the present study aimed to investigate the cardioprotective effects of a preparation obtained from the fruit peels of P. cauliflora (EEPC).Methods: Male New Zealand rabbits received a 1% cholesterol-supplemented diet for 60 days. On the thirtieth day, the animals were divided into five experimental groups and received, once a day, by the oral route, the EEPC (10, 30, and 100 mg/kg), simvastatin (2.5 mg/kg), or vehicle for 30 days. At the end of the experimental period, peripheral blood and arterial branch samples were collected. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), malondialdehyde (MDA), nitrotyrosine (NT), nitrite, interleukin 1 beta (IL-1b), interleukin 6 (IL-6), soluble inter-cellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels were measured. Moreover, the catalase and superoxide dismutase levels were measured on the arterial samples. Histopathological analysis and arterial morphometry were also performed.Results and discussion: The oral administration of ESEG significantly lowered the levels of lipids in rabbits that were fed a CRD diet. This treatment also adjusted the protective system against oxidation in the arteries by decreasing the oxidation of lipids and proteins. Additionally, the levels of IL-1b, IL-6, sICAM-1, and sVCAM-1 in the bloodstream decreased significantly, and this was accompanied by a reduction of atherosclerotic lesions in all branches of the arteries. The findings suggest that EEPC may be a possible option for additional management of atherosclerosis.https://www.frontiersin.org/articles/10.3389/fphar.2024.1244632/fullanti-inflammatoryantioxidantatherosclerosiscardioprotectivejabuticaba |
| spellingShingle | Ana Paula Cestari Francielly Mourão Gasparotto Cândida Aparecida Leite Kassuya Tauany Milan Ribeiro Lacerda Guilherme Donadel Catia Sari Moura Daniela Boleta Ceranto Ezilda Jacomassi Odair Alberton Salviano Belletini Tramontini Luana Ale Bertoncello Arquimedes Gasparotto Junior Emerson Luiz Botelho Lourenço Ateroprotective effects of Plinia cauliflora in. New Zealand rabbits: beyond the lipid-lowering effect Frontiers in Pharmacology anti-inflammatory antioxidant atherosclerosis cardioprotective jabuticaba |
| title | Ateroprotective effects of Plinia cauliflora in. New Zealand rabbits: beyond the lipid-lowering effect |
| title_full | Ateroprotective effects of Plinia cauliflora in. New Zealand rabbits: beyond the lipid-lowering effect |
| title_fullStr | Ateroprotective effects of Plinia cauliflora in. New Zealand rabbits: beyond the lipid-lowering effect |
| title_full_unstemmed | Ateroprotective effects of Plinia cauliflora in. New Zealand rabbits: beyond the lipid-lowering effect |
| title_short | Ateroprotective effects of Plinia cauliflora in. New Zealand rabbits: beyond the lipid-lowering effect |
| title_sort | ateroprotective effects of plinia cauliflora in new zealand rabbits beyond the lipid lowering effect |
| topic | anti-inflammatory antioxidant atherosclerosis cardioprotective jabuticaba |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1244632/full |
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