Synthesis of a New [3-(4-Chlorophenyl)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivative
The new methyl [3-(4-chlorophenyl)-2-{[(2,4-dichloro-1,3-thiazol-5-yl)methylidene]hydrazinylidene}-4-oxo-1,3-thiazolidin-5-ylidene]acetate was synthesized from 4-(4-chlorophenyl)-1-(2,4-dichloro-1,3-thiazol-5-yl)methylidene-3-thiosemicarbazide using dimethyl acetylenedicarboxylate as thia-Michael re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2020/3/M1150 |
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| author | Jacek Szczepański Helena Tuszewska Nazar Trotsko |
| author_facet | Jacek Szczepański Helena Tuszewska Nazar Trotsko |
| author_sort | Jacek Szczepański |
| collection | DOAJ |
| description | The new methyl [3-(4-chlorophenyl)-2-{[(2,4-dichloro-1,3-thiazol-5-yl)methylidene]hydrazinylidene}-4-oxo-1,3-thiazolidin-5-ylidene]acetate was synthesized from 4-(4-chlorophenyl)-1-(2,4-dichloro-1,3-thiazol-5-yl)methylidene-3-thiosemicarbazide using dimethyl acetylenedicarboxylate as thia-Michael reaction acceptor. New compounds (<b>3</b> and <b>4</b>) were characterized by IR, <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy methods. |
| first_indexed | 2024-03-10T18:08:51Z |
| format | Article |
| id | doaj.art-302bfa0a9091463498c973fe218ba9ed |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-10T18:08:51Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-302bfa0a9091463498c973fe218ba9ed2023-11-20T08:17:05ZengMDPI AGMolbank1422-85992020-07-0120203M115010.3390/M1150Synthesis of a New [3-(4-Chlorophenyl)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid DerivativeJacek Szczepański0Helena Tuszewska1Nazar Trotsko2Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki, 20-093 Lublin, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki, 20-093 Lublin, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki, 20-093 Lublin, PolandThe new methyl [3-(4-chlorophenyl)-2-{[(2,4-dichloro-1,3-thiazol-5-yl)methylidene]hydrazinylidene}-4-oxo-1,3-thiazolidin-5-ylidene]acetate was synthesized from 4-(4-chlorophenyl)-1-(2,4-dichloro-1,3-thiazol-5-yl)methylidene-3-thiosemicarbazide using dimethyl acetylenedicarboxylate as thia-Michael reaction acceptor. New compounds (<b>3</b> and <b>4</b>) were characterized by IR, <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy methods.https://www.mdpi.com/1422-8599/2020/3/M1150thiazolidin-4-oneMichael additionanti-<i>T. gondii</i> activity |
| spellingShingle | Jacek Szczepański Helena Tuszewska Nazar Trotsko Synthesis of a New [3-(4-Chlorophenyl)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivative Molbank thiazolidin-4-one Michael addition anti-<i>T. gondii</i> activity |
| title | Synthesis of a New [3-(4-Chlorophenyl)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivative |
| title_full | Synthesis of a New [3-(4-Chlorophenyl)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivative |
| title_fullStr | Synthesis of a New [3-(4-Chlorophenyl)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivative |
| title_full_unstemmed | Synthesis of a New [3-(4-Chlorophenyl)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivative |
| title_short | Synthesis of a New [3-(4-Chlorophenyl)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivative |
| title_sort | synthesis of a new 3 4 chlorophenyl 4 oxo 1 3 thiazolidin 5 ylidene acetic acid derivative |
| topic | thiazolidin-4-one Michael addition anti-<i>T. gondii</i> activity |
| url | https://www.mdpi.com/1422-8599/2020/3/M1150 |
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