One‐carbon metabolism, folate, zinc and translation
Summary The translation process, central to life, is tightly connected to the one‐carbon (1‐C) metabolism via a plethora of macromolecule modifications and specific effectors. Using manual genome annotations and putting together a variety of experimental studies, we explore here the possible reasons...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-07-01
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| Series: | Microbial Biotechnology |
| Online Access: | https://doi.org/10.1111/1751-7915.13550 |
| _version_ | 1818658388729397248 |
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| author | Antoine Danchin Agnieszka Sekowska Conghui You |
| author_facet | Antoine Danchin Agnieszka Sekowska Conghui You |
| author_sort | Antoine Danchin |
| collection | DOAJ |
| description | Summary The translation process, central to life, is tightly connected to the one‐carbon (1‐C) metabolism via a plethora of macromolecule modifications and specific effectors. Using manual genome annotations and putting together a variety of experimental studies, we explore here the possible reasons of this critical interaction, likely to have originated during the earliest steps of the birth of the first cells. Methionine, S‐adenosylmethionine and tetrahydrofolate dominate this interaction. Yet, 1‐C metabolism is unlikely to be a simple frozen accident of primaeval conditions. Reactive 1‐C species (ROCS) are buffered by the translation machinery in a way tightly associated with the metabolism of iron–sulfur clusters, zinc and potassium availability, possibly coupling carbon metabolism to nitrogen metabolism. In this process, the highly modified position 34 of tRNA molecules plays a critical role. Overall, this metabolic integration may serve both as a protection against the deleterious formation of excess carbon under various growth transitions or environmental unbalanced conditions and as a regulator of zinc homeostasis, while regulating input of prosthetic groups into nascent proteins. This knowledge should be taken into account in metabolic engineering. |
| first_indexed | 2024-12-17T03:56:35Z |
| format | Article |
| id | doaj.art-302cb1f0413f4b9586f88f6013bc26da |
| institution | Directory Open Access Journal |
| issn | 1751-7915 |
| language | English |
| last_indexed | 2024-12-17T03:56:35Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Microbial Biotechnology |
| spelling | doaj.art-302cb1f0413f4b9586f88f6013bc26da2022-12-21T22:04:36ZengWileyMicrobial Biotechnology1751-79152020-07-0113489992510.1111/1751-7915.13550One‐carbon metabolism, folate, zinc and translationAntoine Danchin0Agnieszka Sekowska1Conghui You2AMAbiotics SAS Institut Cochin 24 rue du Faubourg Saint‐Jacques 75014 Paris FranceAMAbiotics SAS Institut Cochin 24 rue du Faubourg Saint‐Jacques 75014 Paris FranceShenzhen Key Laboratory of Microbial Genetic Engineering College of Life Sciences and Oceanology Shenzhen University 1066 Xueyuan Rd 518055 Shenzhen ChinaSummary The translation process, central to life, is tightly connected to the one‐carbon (1‐C) metabolism via a plethora of macromolecule modifications and specific effectors. Using manual genome annotations and putting together a variety of experimental studies, we explore here the possible reasons of this critical interaction, likely to have originated during the earliest steps of the birth of the first cells. Methionine, S‐adenosylmethionine and tetrahydrofolate dominate this interaction. Yet, 1‐C metabolism is unlikely to be a simple frozen accident of primaeval conditions. Reactive 1‐C species (ROCS) are buffered by the translation machinery in a way tightly associated with the metabolism of iron–sulfur clusters, zinc and potassium availability, possibly coupling carbon metabolism to nitrogen metabolism. In this process, the highly modified position 34 of tRNA molecules plays a critical role. Overall, this metabolic integration may serve both as a protection against the deleterious formation of excess carbon under various growth transitions or environmental unbalanced conditions and as a regulator of zinc homeostasis, while regulating input of prosthetic groups into nascent proteins. This knowledge should be taken into account in metabolic engineering.https://doi.org/10.1111/1751-7915.13550 |
| spellingShingle | Antoine Danchin Agnieszka Sekowska Conghui You One‐carbon metabolism, folate, zinc and translation Microbial Biotechnology |
| title | One‐carbon metabolism, folate, zinc and translation |
| title_full | One‐carbon metabolism, folate, zinc and translation |
| title_fullStr | One‐carbon metabolism, folate, zinc and translation |
| title_full_unstemmed | One‐carbon metabolism, folate, zinc and translation |
| title_short | One‐carbon metabolism, folate, zinc and translation |
| title_sort | one carbon metabolism folate zinc and translation |
| url | https://doi.org/10.1111/1751-7915.13550 |
| work_keys_str_mv | AT antoinedanchin onecarbonmetabolismfolatezincandtranslation AT agnieszkasekowska onecarbonmetabolismfolatezincandtranslation AT conghuiyou onecarbonmetabolismfolatezincandtranslation |