Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

<p>Abstract</p> <p>Background</p> <p>Current data suggest that an efficacious human immunodeficiency virus type 1 (HIV-1) vaccine should elicit both adaptive humoral and cell mediated immune responses. Such a vaccine will also need to protect against infection from a ra...

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Bibliographic Details
Main Authors: Page Mark, Stebbings Richard, Berry Neil, Hull Robin, Ferguson Deborah, Davis Leanne, Duffy Laura, Elsley William, Hall Joanna, Ham Claire, Hassall Mark, Li Bo, Mee Edward T, Quartey-Papafio Ruby, Rose Nicola J, Mathy Nathalie, Voss Gerald, Stott E, Almond Neil
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Retrovirology
Subjects:
Envelope HIV-1 vaccine
Recombinant gp120
Macaque model
SHIV
Heterologous challenge
Protection
Cynomolgus macaque
Online Access:http://www.retrovirology.com/content/9/1/56

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