Telomere Length of Circulating Cell-Free DNA and Gastric Cancer in a Chinese Population at High-Risk
Background: Telomeres have long been found to be involved in cancer development, while little was known about the dynamic changes of telomere length in carcinogenesis process.Methods: The present study longitudinally investigated telomere alterations of cell-free DNA (cfDNA) in 86 gastric cancer (GC...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.01434/full |
| _version_ | 1819207783588823040 |
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| author | Yu Shi Yang Zhang Lian Zhang Jun-Ling Ma Tong Zhou Zhe-Xuan Li Wei-Dong Liu Wen-Qing Li Da-Jun Deng Wei-Cheng You Kai-Feng Pan |
| author_facet | Yu Shi Yang Zhang Lian Zhang Jun-Ling Ma Tong Zhou Zhe-Xuan Li Wei-Dong Liu Wen-Qing Li Da-Jun Deng Wei-Cheng You Kai-Feng Pan |
| author_sort | Yu Shi |
| collection | DOAJ |
| description | Background: Telomeres have long been found to be involved in cancer development, while little was known about the dynamic changes of telomere length in carcinogenesis process.Methods: The present study longitudinally investigated telomere alterations of cell-free DNA (cfDNA) in 86 gastric cancer (GC) subjects recruited through a 16-year prospective cohort with 2–4 serums collected before each GC-diagnosis from baseline and three follow-up time-points (a total of 276 samples). As the control, 86 individual-matched cancer-free subjects were enrolled with 276 serums from the matched calendar year.Results: In the 73 pairs of baseline serums from GC and control subjects, shortened telomeres showed increased subsequent GC risk [odds ratio (OR) = 9.17, 95% CI: 2.72–31.25 for 1 unit shortening]. In each baseline gastric lesion category, higher risks of GC progression were also found with shortened cfDNA telomeres; ORs per 1 unit shortening were 6.99 (95% CI: 1.63–30.30) for mild gastric lesions, 6.06 (95% CI: 1.89–19.61) for intestinal metaplasia and 15.63 (95% CI: 1.91–125.00) for dysplasia. With all measurements from baseline and follow-up time-points, shortened telomeres also showed significant association with GC risk (OR = 7.37, 95% CI: 2.06–26.32 for 1 unit shortening). In temporal trend analysis, shortened telomeres were found in GC subjects compared to corresponding controls more than 3 years ahead of GC-diagnosis (most P < 0.05), while no significant difference was found between two groups within 3 years approaching to GC-diagnosis.Conclusion: Our findings suggest that telomere shortening may be associated with gastric carcinogenesis, which supports further etiological study and potential biomarker for risk stratification. |
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| id | doaj.art-30311f096f3b4c5c908a12082480948d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T05:28:59Z |
| publishDate | 2019-12-01 |
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| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-30311f096f3b4c5c908a12082480948d2022-12-21T17:58:31ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-12-01910.3389/fonc.2019.01434459976Telomere Length of Circulating Cell-Free DNA and Gastric Cancer in a Chinese Population at High-RiskYu Shi0Yang Zhang1Lian Zhang2Jun-Ling Ma3Tong Zhou4Zhe-Xuan Li5Wei-Dong Liu6Wen-Qing Li7Da-Jun Deng8Wei-Cheng You9Kai-Feng Pan10Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, ChinaLinqu Public Health Bureau, Shandong, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Etiology, Peking University Cancer Hospital and Institute, Beijing, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, ChinaBackground: Telomeres have long been found to be involved in cancer development, while little was known about the dynamic changes of telomere length in carcinogenesis process.Methods: The present study longitudinally investigated telomere alterations of cell-free DNA (cfDNA) in 86 gastric cancer (GC) subjects recruited through a 16-year prospective cohort with 2–4 serums collected before each GC-diagnosis from baseline and three follow-up time-points (a total of 276 samples). As the control, 86 individual-matched cancer-free subjects were enrolled with 276 serums from the matched calendar year.Results: In the 73 pairs of baseline serums from GC and control subjects, shortened telomeres showed increased subsequent GC risk [odds ratio (OR) = 9.17, 95% CI: 2.72–31.25 for 1 unit shortening]. In each baseline gastric lesion category, higher risks of GC progression were also found with shortened cfDNA telomeres; ORs per 1 unit shortening were 6.99 (95% CI: 1.63–30.30) for mild gastric lesions, 6.06 (95% CI: 1.89–19.61) for intestinal metaplasia and 15.63 (95% CI: 1.91–125.00) for dysplasia. With all measurements from baseline and follow-up time-points, shortened telomeres also showed significant association with GC risk (OR = 7.37, 95% CI: 2.06–26.32 for 1 unit shortening). In temporal trend analysis, shortened telomeres were found in GC subjects compared to corresponding controls more than 3 years ahead of GC-diagnosis (most P < 0.05), while no significant difference was found between two groups within 3 years approaching to GC-diagnosis.Conclusion: Our findings suggest that telomere shortening may be associated with gastric carcinogenesis, which supports further etiological study and potential biomarker for risk stratification.https://www.frontiersin.org/article/10.3389/fonc.2019.01434/fullcell-free DNAprospective cohortgastric cancerserumtelomere length |
| spellingShingle | Yu Shi Yang Zhang Lian Zhang Jun-Ling Ma Tong Zhou Zhe-Xuan Li Wei-Dong Liu Wen-Qing Li Da-Jun Deng Wei-Cheng You Kai-Feng Pan Telomere Length of Circulating Cell-Free DNA and Gastric Cancer in a Chinese Population at High-Risk Frontiers in Oncology cell-free DNA prospective cohort gastric cancer serum telomere length |
| title | Telomere Length of Circulating Cell-Free DNA and Gastric Cancer in a Chinese Population at High-Risk |
| title_full | Telomere Length of Circulating Cell-Free DNA and Gastric Cancer in a Chinese Population at High-Risk |
| title_fullStr | Telomere Length of Circulating Cell-Free DNA and Gastric Cancer in a Chinese Population at High-Risk |
| title_full_unstemmed | Telomere Length of Circulating Cell-Free DNA and Gastric Cancer in a Chinese Population at High-Risk |
| title_short | Telomere Length of Circulating Cell-Free DNA and Gastric Cancer in a Chinese Population at High-Risk |
| title_sort | telomere length of circulating cell free dna and gastric cancer in a chinese population at high risk |
| topic | cell-free DNA prospective cohort gastric cancer serum telomere length |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.01434/full |
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