Synthesis and Evaluation of Trypanocidal Activity of Chromane-Type Compounds and Acetophenones

Synthesis and Evaluation of Trypanocidal Activity of Chromane-Type Compounds and Acetophenones

American trypanosomiasis (Chagas disease) caused by the <i>Trypanosoma cruzi</i> parasite, is a severe health problem in different regions of Latin America and is currently reported to be spreading to Europe, North America, Japan, and Australia, due to the migration of populations from S...

Full description

Bibliographic Details
Main Authors:	Luis A. González, Sara Robledo, Yulieth Upegui, Gustavo Escobar, Wiston Quiñones
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	Molecules
Subjects:	<i>Trypanosoma cruzi</i> chromane phenolic compounds prenyl derivatives
Online Access:	https://www.mdpi.com/1420-3049/26/23/7067

Similar Items

Synthesis of 4-(4-chlorophenyl)thiazole compounds: in silico and in vitro evaluations as leishmanicidal and trypanocidal agents
by: IRANILDO JOSÉ DA CRUZ FILHO, et al.
Published: (2023-05-01)

Two New Chroman Derivations from the Endophytic Penicillium sp. DCS523
by: Qi Wang, et al.
Published: (2011-01-01)

Chromane Derivatives from Underground Parts of <i>Iris tenuifolia</i> and Their In Vitro Antimicrobial, Cytotoxicity and Antiproliferative Evaluation
by: Oldokh Otgon, et al.
Published: (2021-11-01)

Trypanocidal Activity of Flavanone Derivatives
by: Gabriela Maciel Diogo, et al.
Published: (2020-01-01)

Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives
by: Qianqian Sun, et al.
Published: (2023-04-01)

Insights into Ergosterol Peroxide’s Trypanocidal Activity
by: Thuluz Meza-Menchaca, et al.
Published: (2019-09-01)

Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2<i>H</i>)-one Derivatives
by: Zuleima Blanco, et al.
Published: (2022-08-01)

Reactions of salicylaldehyde and enolates or their equivalents: versatile synthetic routes to chromane derivatives
by: Ishmael B. Masesane, et al.
Published: (2012-12-01)

Trypanocidal Activity of Four Sesquiterpene Lactones Isolated from Asteraceae Species
by: Orlando G. Elso, et al.
Published: (2020-04-01)

Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities
by: Rawat P, et al.
Published: (2016-09-01)

Redox-neutral and metal-free synthesis of 3-(arylmethyl)chroman-4-ones via visible-light-driven alkene acylarylation
by: Yan Ding, et al.
Published: (2022-10-01)

Synthesis of New Dehydrodieugenol Derivatives via Olefin Cross Metathesis and In Vitro Evaluation of Their Trypanocidal Activity
by: Thalita S. Galhardo, et al.
Published: (2023-07-01)

The Trypanocidal Activity of Naphthoquinones: A Review
by: Solange Lisboa de Castro, et al.
Published: (2009-11-01)

Cytotoxicity and trypanocidal activity of nifurtimox encapsulated in ethylcyanoacrylate nanoparticles
by: GITTITH SÁNCHEZ, et al.
Published: (2002-01-01)

TrypanocidalActivity of Natural Sesquiterpenoids Involves Mitochondrial Dysfunction, ROS Production and Autophagic Phenotype in <i>Trypanosoma cruzi</i>
by: Ana Cristina Souza Bombaça, et al.
Published: (2018-10-01)

Gold(I)-catalysed one-pot synthesis of chromans using allylic alcohols and phenols
by: Eloi Coutant, et al.
Published: (2013-09-01)

Trypanocidal and Anti-Inflammatory Effects of Three <i>ent</i>-Kaurane Diterpenoids from <i>Gymnocoronis spilanthoides</i> var. <i>subcordata</i> (Asteraceae)
by: Mariana G. Selener, et al.
Published: (2024-03-01)

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
by: Ana L. Legarda-Ceballos, et al.
Published: (2015-06-01)

Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents
by: Francisco Salgado, et al.
Published: (2021-03-01)

Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents
by: Lenci K. Vázquez-Jiménez, et al.
Published: (2022-09-01)

Antidiabetic effect of new chromane isolated from Dillenia indica L. leaves in streptozotocin induced diabetic rats
by: Navpreet Kaur, et al.
Published: (2016-04-01)

Water-Tolerant Trifloaluminate Ionic Liquids: New and Unique Lewis Acidic Catalysts for the Synthesis of Chromane
by: Piotr Latos, et al.
Published: (2018-11-01)

Enantiodivergent synthesis of tricyclic chromans: Remote nucleophilic groups switch selectivity in catalytic asymmetric cascade reactions of trifunctional substrates
by: Zhongwen Sun, et al.
Published: (2021-05-01)

Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against <i>Trypanosoma cruzi</i>
by: Leonardo S. Lara, et al.
Published: (2021-01-01)

cis-Diastereoselective synthesis of chroman-fused tetralins as B-ring-modified analogues of brazilin
by: Dimpee Gogoi, et al.
Published: (2016-12-01)

<i>Trypanosoma cruzi</i> Secreted Cyclophilin <i>Tc</i>CyP19 as an Early Marker for Trypanocidal Treatment Efficiency
by: Alina E. Perrone, et al.
Published: (2023-07-01)

Enantioselective Michael/Hemiketalization Cascade Reactions between Hydroxymaleimides and 2-Hydroxynitrostyrenes for the Construction of Chiral Chroman-Fused Pyrrolidinediones
by: Dong-Hua Xie, et al.
Published: (2022-08-01)

Synthesis of (-) - 6,6'-dinitrohinokinin from hinokinin natural product and in silico and in vitro trypanocidal activity assessment
by: Suziene Caroline Silva Cardoso, et al.
Published: (2024-03-01)

Heteroleptic Oxidovanadium(V) Complexes with Activity against Infective and Non-Infective Stages of <i>Trypanosoma cruzi</i>
by: Gonzalo Scalese, et al.
Published: (2021-09-01)

Catalytic asymmetric tandem Friedel–Crafts alkylation/Michael addition reaction for the synthesis of highly functionalized chromans
by: Jiahuan Peng, et al.
Published: (2013-06-01)

Trypanocidal constituents in plants: 7. Mammea-type coumarins
by: Ricardo Reyes-Chilpa, et al.
Published: (2008-08-01)

Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi
by: João S. Silva, et al.
Published: (1992-09-01)

Potent Antibacterial Prenylated Acetophenones from the Australian Endemic Plant <i>Acronychia crassipetala</i>
by: Trong D. Tran, et al.
Published: (2020-08-01)

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme
by: Alcione Silva de Carvalho, et al.
Published: (2014-06-01)

Immunomodulation and Antioxidant Activities as Possible Trypanocidal and Cardioprotective Mechanisms of Major Terpenes from <i>Lippia alba</i> Essential Oils in an Experimental Model of Chronic Chagas Disease
by: Denerieth Ximena Espinel-Mesa, et al.
Published: (2021-11-01)

Dipyridamole potentiated the trypanocidal effect of nifurtimox and improved the cardiac function in NMRI mice with acute chagasic myocarditis
by: Sonia Santeliz, et al.

Stereochemistry of Chiral 2-Substituted Chromanes: Twist of the Dihydropyran Ring and Specific Optical Rotation
by: Bei-Bei Yang, et al.
Published: (2023-01-01)

Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study
by: De Moura Kelly C. G., et al.
Published: (2001-01-01)

Identification of Inhibitors to <i>Trypanosoma cruzi</i> Sirtuins Based on Compounds Developed to Human Enzymes
by: Tanira Matutino Bastos, et al.
Published: (2020-05-01)

Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons
by: Elizabeth Bilsland, et al.
Published: (2018-04-01)