Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.

Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.

BACKGROUND:The INK4/ARF locus encodes three tumor suppressor genes (p15(Ink4b), Arf and p16(Ink4a)) and is frequently inactivated in a large number of human cancers. Mechanisms regulating INK4/ARF expression are not fully characterized. PRINCIPAL FINDINGS:Here we show that in young proliferating emb...

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Bibliographic Details
Main Authors: Hanane Agherbi, Anne Gaussmann-Wenger, Christophe Verthuy, Lionel Chasson, Manuel Serrano, Malek Djabali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2680618?pdf=render

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