Enteral Linezolid as an Effective Option to Treat an Extremely Preterm Infant with <i>Bacillus cereus</i> Sepsis
We report the safe and effective use of oral linezolid for treatment of <i>Bacillus cereus</i> sepsis in an extremely preterm neonate, previously fed with human donor milk, in which a <i>Brevibacillus</i> sp. was eventually found. Due to several predisposing factors, prematur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/3/415 |
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| author | Chiara Minotti Luca Bonadies Cecilia Liberati Marica De Pieri Carlo Giaquinto Eugenio Baraldi Daniele Donà |
| author_facet | Chiara Minotti Luca Bonadies Cecilia Liberati Marica De Pieri Carlo Giaquinto Eugenio Baraldi Daniele Donà |
| author_sort | Chiara Minotti |
| collection | DOAJ |
| description | We report the safe and effective use of oral linezolid for treatment of <i>Bacillus cereus</i> sepsis in an extremely preterm neonate, previously fed with human donor milk, in which a <i>Brevibacillus</i> sp. was eventually found. Due to several predisposing factors, premature, very low birth weight newborns are extremely vulnerable to invasive infections by environmental pathogens. After vancomycin microbiologic treatment failure (despite adequate blood concentrations and clinical response), linezolid was chosen for its optimal enteral absorption and bioavailability, also after exhaustion of peripheral venous heritage. No adverse events were recorded, with clinical cure. We reviewed the literature on <i>B. cereus</i> infections in newborns, together with the available evidence on the use of linezolid in similar contexts. |
| first_indexed | 2024-03-09T19:59:45Z |
| format | Article |
| id | doaj.art-3031ffd9b7bc4dc4a5b946f3ad23630c |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T19:59:45Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-3031ffd9b7bc4dc4a5b946f3ad23630c2023-11-24T00:47:46ZengMDPI AGChildren2227-90672022-03-019341510.3390/children9030415Enteral Linezolid as an Effective Option to Treat an Extremely Preterm Infant with <i>Bacillus cereus</i> SepsisChiara Minotti0Luca Bonadies1Cecilia Liberati2Marica De Pieri3Carlo Giaquinto4Eugenio Baraldi5Daniele Donà6Division of Pediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, ItalyNeonatal Intensive Care Unit, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, ItalyDivision of Pediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, ItalyDivision of Pediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, ItalyDivision of Pediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, ItalyNeonatal Intensive Care Unit, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, ItalyDivision of Pediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, ItalyWe report the safe and effective use of oral linezolid for treatment of <i>Bacillus cereus</i> sepsis in an extremely preterm neonate, previously fed with human donor milk, in which a <i>Brevibacillus</i> sp. was eventually found. Due to several predisposing factors, premature, very low birth weight newborns are extremely vulnerable to invasive infections by environmental pathogens. After vancomycin microbiologic treatment failure (despite adequate blood concentrations and clinical response), linezolid was chosen for its optimal enteral absorption and bioavailability, also after exhaustion of peripheral venous heritage. No adverse events were recorded, with clinical cure. We reviewed the literature on <i>B. cereus</i> infections in newborns, together with the available evidence on the use of linezolid in similar contexts.https://www.mdpi.com/2227-9067/9/3/415pretermnewbornlinezolid<i>B. cereus</i>invasive infectionsepsis |
| spellingShingle | Chiara Minotti Luca Bonadies Cecilia Liberati Marica De Pieri Carlo Giaquinto Eugenio Baraldi Daniele Donà Enteral Linezolid as an Effective Option to Treat an Extremely Preterm Infant with <i>Bacillus cereus</i> Sepsis Children preterm newborn linezolid <i>B. cereus</i> invasive infection sepsis |
| title | Enteral Linezolid as an Effective Option to Treat an Extremely Preterm Infant with <i>Bacillus cereus</i> Sepsis |
| title_full | Enteral Linezolid as an Effective Option to Treat an Extremely Preterm Infant with <i>Bacillus cereus</i> Sepsis |
| title_fullStr | Enteral Linezolid as an Effective Option to Treat an Extremely Preterm Infant with <i>Bacillus cereus</i> Sepsis |
| title_full_unstemmed | Enteral Linezolid as an Effective Option to Treat an Extremely Preterm Infant with <i>Bacillus cereus</i> Sepsis |
| title_short | Enteral Linezolid as an Effective Option to Treat an Extremely Preterm Infant with <i>Bacillus cereus</i> Sepsis |
| title_sort | enteral linezolid as an effective option to treat an extremely preterm infant with i bacillus cereus i sepsis |
| topic | preterm newborn linezolid <i>B. cereus</i> invasive infection sepsis |
| url | https://www.mdpi.com/2227-9067/9/3/415 |
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