Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen
Total polysaccharides of Pinus massoniana Lamb. pollen (PPPSt) is a natural carbohydrate with known anti-inflammatory effects. Inflammation was the main cause of death due to myocardial damage caused by sepsis. The aim of this study was to investigate the potential protective effect of PPPSt on the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893923000932 |
| _version_ | 1797383643387133952 |
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| author | Cheng Wang Hongqi Shang Shuyu Zhang Xiangkun Wang Mingyue Shen Ning Li Defeng Liu Yunxuan Jiang Kai Wei Ruiliang Zhu |
| author_facet | Cheng Wang Hongqi Shang Shuyu Zhang Xiangkun Wang Mingyue Shen Ning Li Defeng Liu Yunxuan Jiang Kai Wei Ruiliang Zhu |
| author_sort | Cheng Wang |
| collection | DOAJ |
| description | Total polysaccharides of Pinus massoniana Lamb. pollen (PPPSt) is a natural carbohydrate with known anti-inflammatory effects. Inflammation was the main cause of death due to myocardial damage caused by sepsis. The aim of this study was to investigate the potential protective effect of PPPSt on the septic myocardial injury. Lipopolysaccharide (LPS) was injected intraperitoneally to establish the myocardial injury model and PPPS was used for intervention, then the changes in myocardial enzymes, myocardial tissue morphology, oxidative stress, and inflammation levels were evaluated experimentally. The results showed that PPPSt could alleviate the LPS-induced increase of aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK) levels, and also ameliorate the histopathological damage of myocardium, but PPPSt had no protective effect on oxidative stress injury. In terms of inflammation, PPPSt treatment can significantly reduce the levels of IL-1β and NO in the serum. In addition, PPPSt can also down-regulate the phosphorylation of Nuclear factor kappa beta (NFκB) and NFκB inhibitor alpha (IKBα) in the septic myocardial tissue, and inhibit the activation of NFκB signaling pathway. In conclusion, PPPSt can protect against LPS-induced septic myocardial injury in chicks, which provides a theoretical basis for the potential treatment of septic myocardial injury. |
| first_indexed | 2024-03-08T21:24:02Z |
| format | Article |
| id | doaj.art-3032e78ca66a4116b7764c9511cb30ef |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-03-08T21:24:02Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-3032e78ca66a4116b7764c9511cb30ef2023-12-21T07:37:45ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392023-12-016100372Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollenCheng Wang0Hongqi Shang1Shuyu Zhang2Xiangkun Wang3Mingyue Shen4Ning Li5Defeng Liu6Yunxuan Jiang7Kai Wei8Ruiliang Zhu9Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, China; Shandong Academy of Chinese Medicine, Jinan, Shandong, 250014, ChinaShandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, ChinaShandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, ChinaShandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, ChinaShandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, ChinaShandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, ChinaShandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, ChinaShandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, ChinaShandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, ChinaShandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai`an, Shandong, 271018, China; Corresponding author.Total polysaccharides of Pinus massoniana Lamb. pollen (PPPSt) is a natural carbohydrate with known anti-inflammatory effects. Inflammation was the main cause of death due to myocardial damage caused by sepsis. The aim of this study was to investigate the potential protective effect of PPPSt on the septic myocardial injury. Lipopolysaccharide (LPS) was injected intraperitoneally to establish the myocardial injury model and PPPS was used for intervention, then the changes in myocardial enzymes, myocardial tissue morphology, oxidative stress, and inflammation levels were evaluated experimentally. The results showed that PPPSt could alleviate the LPS-induced increase of aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK) levels, and also ameliorate the histopathological damage of myocardium, but PPPSt had no protective effect on oxidative stress injury. In terms of inflammation, PPPSt treatment can significantly reduce the levels of IL-1β and NO in the serum. In addition, PPPSt can also down-regulate the phosphorylation of Nuclear factor kappa beta (NFκB) and NFκB inhibitor alpha (IKBα) in the septic myocardial tissue, and inhibit the activation of NFκB signaling pathway. In conclusion, PPPSt can protect against LPS-induced septic myocardial injury in chicks, which provides a theoretical basis for the potential treatment of septic myocardial injury.http://www.sciencedirect.com/science/article/pii/S2666893923000932Total polysaccharides of Pinus massoniana Lamb. pollenSepsisMyocardial injuryInflammatory factors septic myocardial injury in chicksNFκB signaling pathway |
| spellingShingle | Cheng Wang Hongqi Shang Shuyu Zhang Xiangkun Wang Mingyue Shen Ning Li Defeng Liu Yunxuan Jiang Kai Wei Ruiliang Zhu Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen Carbohydrate Polymer Technologies and Applications Total polysaccharides of Pinus massoniana Lamb. pollen Sepsis Myocardial injury Inflammatory factors septic myocardial injury in chicks NFκB signaling pathway |
| title | Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen |
| title_full | Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen |
| title_fullStr | Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen |
| title_full_unstemmed | Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen |
| title_short | Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen |
| title_sort | inhibitions inflammatory response in clicks alleviates lps induced myocardial injury by total polysaccharides of pinus massoniana lamb pollen |
| topic | Total polysaccharides of Pinus massoniana Lamb. pollen Sepsis Myocardial injury Inflammatory factors septic myocardial injury in chicks NFκB signaling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S2666893923000932 |
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