Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review
Background and aim: Tuberculosis (TB) is associated with a high mortality in the intensive care unit (ICU), especially in subjects with Acute Respiratory Distress Syndrome (ARDS) requiring mechanical ventilation. Despite its global burden on morbidity and mortality, TB is an uncommon cause of ICU ad...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2022-07-01
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| Series: | Pulmonology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531043722000289 |
| _version_ | 1811231387094614016 |
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| author | J. Galvin S. Tiberi O. Akkerman H.A.M. Kerstjens H. Kunst X. Kurhasani N. Ambrosino G.B. Migliori |
| author_facet | J. Galvin S. Tiberi O. Akkerman H.A.M. Kerstjens H. Kunst X. Kurhasani N. Ambrosino G.B. Migliori |
| author_sort | J. Galvin |
| collection | DOAJ |
| description | Background and aim: Tuberculosis (TB) is associated with a high mortality in the intensive care unit (ICU), especially in subjects with Acute Respiratory Distress Syndrome (ARDS) requiring mechanical ventilation. Despite its global burden on morbidity and mortality, TB is an uncommon cause of ICU admission, however mortality is disproportionate to the advances in diagnosis and treatment made. Herein we report a systematic review of published studies. Methods: Our Literature search was conducted to identify studies on outcomes of individuals with TB admitted to ICU. We report and review in-hospital mortality, predictors of poorer outcomes, usefulness of severity scoring systems and potential benefits of intravenous antibiotics. Searches from Pubmed, Embase, Cochrane and Medline were conducted from inception to March 2020. Only literature in English was included. Results: Out of 529 potentially relevant articles, 17 were included. Mortality across all studies ranged from 29-95% with an average of 52.9%. All severity scores underestimated average mortality. The most common indication for ICU admission was acute respiratory failure (36.3%). Negative predictors of outcome included hospital acquired infections, need of mechanical ventilation and vasopressors, delay in initiation of anti-TB treatment, more than one organ failure and a higher severity score. Low income, high incidence countries showed a 23.4% higher mortality rate compared to high income, low TB incidence countries. Conclusion: Mortality in individuals with TB admitted to ICU is high. Earlier detection and treatment initiation is needed. |
| first_indexed | 2024-04-12T10:44:26Z |
| format | Article |
| id | doaj.art-30338818671e49afb9788a0ae3327777 |
| institution | Directory Open Access Journal |
| issn | 2531-0437 |
| language | English |
| last_indexed | 2024-04-12T10:44:26Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Pulmonology |
| spelling | doaj.art-30338818671e49afb9788a0ae33277772022-12-22T03:36:29ZengElsevier EspañaPulmonology2531-04372022-07-01284297309Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic reviewJ. Galvin0S. Tiberi1O. Akkerman2H.A.M. Kerstjens3H. Kunst4X. Kurhasani5N. Ambrosino6G.B. Migliori7Department of Infection, The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United KingdomDepartment of Infection, The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United KingdomDepartment of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, the Netherland; University of Groningen, University Medical Center Groningen, Tuberculosis center Beatrixoord, Haren, the NetherlandsDepartment of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, the Netherland; University of Groningen, University Medical Center Groningen, Tuberculosis center Beatrixoord, Haren, the NetherlandsBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom; Department of Respiratory Medicine, Barts Health NHS Trust, London, UKUBT Higher Education Prishtina, KosovoPneumology Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Montescano, ItalyServizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri, IRCCS, Via Roncaccio 16, Tradate 21049, Italy; Corresponding author.Background and aim: Tuberculosis (TB) is associated with a high mortality in the intensive care unit (ICU), especially in subjects with Acute Respiratory Distress Syndrome (ARDS) requiring mechanical ventilation. Despite its global burden on morbidity and mortality, TB is an uncommon cause of ICU admission, however mortality is disproportionate to the advances in diagnosis and treatment made. Herein we report a systematic review of published studies. Methods: Our Literature search was conducted to identify studies on outcomes of individuals with TB admitted to ICU. We report and review in-hospital mortality, predictors of poorer outcomes, usefulness of severity scoring systems and potential benefits of intravenous antibiotics. Searches from Pubmed, Embase, Cochrane and Medline were conducted from inception to March 2020. Only literature in English was included. Results: Out of 529 potentially relevant articles, 17 were included. Mortality across all studies ranged from 29-95% with an average of 52.9%. All severity scores underestimated average mortality. The most common indication for ICU admission was acute respiratory failure (36.3%). Negative predictors of outcome included hospital acquired infections, need of mechanical ventilation and vasopressors, delay in initiation of anti-TB treatment, more than one organ failure and a higher severity score. Low income, high incidence countries showed a 23.4% higher mortality rate compared to high income, low TB incidence countries. Conclusion: Mortality in individuals with TB admitted to ICU is high. Earlier detection and treatment initiation is needed.http://www.sciencedirect.com/science/article/pii/S2531043722000289TuberculosisIntensive careMortalityAcute respiratory distress syndromeIntravenous antimicrobials |
| spellingShingle | J. Galvin S. Tiberi O. Akkerman H.A.M. Kerstjens H. Kunst X. Kurhasani N. Ambrosino G.B. Migliori Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review Pulmonology Tuberculosis Intensive care Mortality Acute respiratory distress syndrome Intravenous antimicrobials |
| title | Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review |
| title_full | Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review |
| title_fullStr | Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review |
| title_full_unstemmed | Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review |
| title_short | Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review |
| title_sort | pulmonary tuberculosis in intensive care setting with a focus on the use of severity scores a multinational collaborative systematic review |
| topic | Tuberculosis Intensive care Mortality Acute respiratory distress syndrome Intravenous antimicrobials |
| url | http://www.sciencedirect.com/science/article/pii/S2531043722000289 |
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