Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression

Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression

Abstract Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and their contribution to its mechanism of action as an antidepressant, are still unclear. We investigated ketamine...

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Bibliographic Details
Main Authors: Lily R. Aleksandrova, Yu Tian Wang, Anthony G. Phillips
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Brain
Subjects:
Ketamine
Synaptic plasticity
LTP
Hippocampus
HNK
Antidepressant
Online Access:http://link.springer.com/article/10.1186/s13041-020-00627-z

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