Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in China
Ochratoxin A (OTA) is a mycotoxin found in a variety of foods and herbal medicines, and several governmental bodies around the world have set maximum allowable levels of OTA in different foods and herbal medicines. This study aims to evaluate the health risk of OTA in Astragali Radix (AR) in China,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322003578 |
| _version_ | 1818441016569495552 |
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| author | Yin Zhu Shaomin Wang Xiaohui Xu Lingling Wang Heng Zhou Xuanyu Ying Qing Hu Xinglong Wang Shen Ji Qiang Cai |
| author_facet | Yin Zhu Shaomin Wang Xiaohui Xu Lingling Wang Heng Zhou Xuanyu Ying Qing Hu Xinglong Wang Shen Ji Qiang Cai |
| author_sort | Yin Zhu |
| collection | DOAJ |
| description | Ochratoxin A (OTA) is a mycotoxin found in a variety of foods and herbal medicines, and several governmental bodies around the world have set maximum allowable levels of OTA in different foods and herbal medicines. This study aims to evaluate the health risk of OTA in Astragali Radix (AR) in China, and to evaluate the effects of different limit levels on the risk control of OTA in AR. The concentrations of OTA in 187 samples of AR were investigated, and 61 (32.6%) samples were positive. The mean, 50th and 95th percentile values of OTA in positive samples were 56.2, 5.1 and 304.5 μg/kg, respectively. A margin of exposure (MOE) approach was applied to assess the risk. Considering other food sources, long-term consumers have a relatively high risk of OTA exposure due to the ingestion of AR. Theoretical limit levels of OTA in AR were evaluated from two dimensions by weighing the costs and the benefits. The results indicated that the limit levels that might be applied to the management of OTA contamination in AR in China could be screened out through risk-based evaluation of limit levels. |
| first_indexed | 2024-12-14T18:21:33Z |
| format | Article |
| id | doaj.art-303580a577db4f07a4700e9a59ace55f |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-14T18:21:33Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-303580a577db4f07a4700e9a59ace55f2022-12-21T22:52:03ZengElsevierEcotoxicology and Environmental Safety0147-65132022-06-01237113517Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in ChinaYin Zhu0Shaomin Wang1Xiaohui Xu2Lingling Wang3Heng Zhou4Xuanyu Ying5Qing Hu6Xinglong Wang7Shen Ji8Qiang Cai9Shanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai 201203, China; Yangtze Delta Region Institute of Tsinghua University, Zhejiang 314006, ChinaShanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai 201203, ChinaYangtze Delta Region Institute of Tsinghua University, Zhejiang 314006, ChinaShandong Academy of Chinese Medicine, Shandong 250014, ChinaShanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai 201203, ChinaYangtze Delta Region Institute of Tsinghua University, Zhejiang 314006, ChinaShanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai 201203, ChinaYangtze Delta Region Institute of Tsinghua University, Zhejiang 314006, ChinaShanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai 201203, China; Corresponding authors.Yangtze Delta Region Institute of Tsinghua University, Zhejiang 314006, China; Corresponding authors.Ochratoxin A (OTA) is a mycotoxin found in a variety of foods and herbal medicines, and several governmental bodies around the world have set maximum allowable levels of OTA in different foods and herbal medicines. This study aims to evaluate the health risk of OTA in Astragali Radix (AR) in China, and to evaluate the effects of different limit levels on the risk control of OTA in AR. The concentrations of OTA in 187 samples of AR were investigated, and 61 (32.6%) samples were positive. The mean, 50th and 95th percentile values of OTA in positive samples were 56.2, 5.1 and 304.5 μg/kg, respectively. A margin of exposure (MOE) approach was applied to assess the risk. Considering other food sources, long-term consumers have a relatively high risk of OTA exposure due to the ingestion of AR. Theoretical limit levels of OTA in AR were evaluated from two dimensions by weighing the costs and the benefits. The results indicated that the limit levels that might be applied to the management of OTA contamination in AR in China could be screened out through risk-based evaluation of limit levels.http://www.sciencedirect.com/science/article/pii/S0147651322003578Astragali RadixOchratoxin AExposure assessmentHealth riskLimit levelTraditional Chinese medicine |
| spellingShingle | Yin Zhu Shaomin Wang Xiaohui Xu Lingling Wang Heng Zhou Xuanyu Ying Qing Hu Xinglong Wang Shen Ji Qiang Cai Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in China Ecotoxicology and Environmental Safety Astragali Radix Ochratoxin A Exposure assessment Health risk Limit level Traditional Chinese medicine |
| title | Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in China |
| title_full | Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in China |
| title_fullStr | Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in China |
| title_full_unstemmed | Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in China |
| title_short | Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in China |
| title_sort | exposure assessment and risk based limit levels evaluation of ochratoxin a in astragali radix in china |
| topic | Astragali Radix Ochratoxin A Exposure assessment Health risk Limit level Traditional Chinese medicine |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322003578 |
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