Impacts of delivery mode on very low birth weight infants’ oral microbiome
Objectives: Initial microbial colonization of the oral after birth provides a vital stimulus for neonatal immune and development. The establishment of the gut microbiota has been shown to differ between very low birth weight (VLBW) infants delivered by caesarian section (C-section) and those deliver...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957219305273 |
| _version_ | 1826574884726112256 |
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| author | Hongping Li Yong Zhang Bin Xiao Shanqiu Xiao Jiaman Wu Weimin Huang |
| author_facet | Hongping Li Yong Zhang Bin Xiao Shanqiu Xiao Jiaman Wu Weimin Huang |
| author_sort | Hongping Li |
| collection | DOAJ |
| description | Objectives: Initial microbial colonization of the oral after birth provides a vital stimulus for neonatal immune and development. The establishment of the gut microbiota has been shown to differ between very low birth weight (VLBW) infants delivered by caesarian section (C-section) and those delivered vaginally. The objective of this study was to investigate the community structure of the oral microbiota in VLBW infants delivered by the two modes. Methods: In total, 23 VLBW infants who were hospitalized in the neonatal intensive care unit of Shenzhen BaoAn Maternity & Child Health care Hospital (Shenzhen, China) were recruited for this study: 12 infants delivered vaginally, and the other 11 infants delivered by C-section. The assessment of oral microbiota community was performed using 16S rRNA gene sequence analysis. Results: The results demonstrated that the oral bacterial communities were dominated by the phylum Proteobacteria in both groups. Higher relative abundance of genera Ureaplasma and Pantoea were observed in the vaginal delivery infants, but genera Corynebacterium, Methylobacterium and Variovorax were more prevalent in cesarean-born infants. Furthermore, many metabolic pathways with significant differences between the two groups were detected, mostly related to vitamin, amino acid metabolism and diseases. Additionally, ɑ-diversity and clinical data showed no significant differences between the two groups. Conclusions: This study indicated that the mode of delivery influences the oral bacterial structure of VLBW infants after birth, but the consequences for neonatal development should be researched in a further study. Key Words: oral microbiota, very low birth weight infants, the mode of delivery, 16s rRNA gene sequencing |
| first_indexed | 2024-12-12T20:18:55Z |
| format | Article |
| id | doaj.art-3035fdac3b904707ab4bdc4bd9441a09 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2025-03-14T13:05:54Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-3035fdac3b904707ab4bdc4bd9441a092025-03-02T01:21:24ZengElsevierPediatrics and Neonatology1875-95722020-04-01612201209Impacts of delivery mode on very low birth weight infants’ oral microbiomeHongping Li0Yong Zhang1Bin Xiao2Shanqiu Xiao3Jiaman Wu4Weimin Huang5Shenzhen Children's Hospital of China Medical University, Shenzhen, 518000, ChinaGuangdong Provincial Maternity & Child Healthcare Hospital, Guangzhou, 510010, ChinaShenzhen BaoAn Maternity & Child Healthcare Hospital, Shenzhen, 518000, ChinaShenzhen BaoAn Maternity & Child Healthcare Hospital, Shenzhen, 518000, ChinaAffiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, 518000, China; Corresponding author.Shenzhen Children's Hospital of China Medical University, Shenzhen, 518000, China; Corresponding author.Objectives: Initial microbial colonization of the oral after birth provides a vital stimulus for neonatal immune and development. The establishment of the gut microbiota has been shown to differ between very low birth weight (VLBW) infants delivered by caesarian section (C-section) and those delivered vaginally. The objective of this study was to investigate the community structure of the oral microbiota in VLBW infants delivered by the two modes. Methods: In total, 23 VLBW infants who were hospitalized in the neonatal intensive care unit of Shenzhen BaoAn Maternity & Child Health care Hospital (Shenzhen, China) were recruited for this study: 12 infants delivered vaginally, and the other 11 infants delivered by C-section. The assessment of oral microbiota community was performed using 16S rRNA gene sequence analysis. Results: The results demonstrated that the oral bacterial communities were dominated by the phylum Proteobacteria in both groups. Higher relative abundance of genera Ureaplasma and Pantoea were observed in the vaginal delivery infants, but genera Corynebacterium, Methylobacterium and Variovorax were more prevalent in cesarean-born infants. Furthermore, many metabolic pathways with significant differences between the two groups were detected, mostly related to vitamin, amino acid metabolism and diseases. Additionally, ɑ-diversity and clinical data showed no significant differences between the two groups. Conclusions: This study indicated that the mode of delivery influences the oral bacterial structure of VLBW infants after birth, but the consequences for neonatal development should be researched in a further study. Key Words: oral microbiota, very low birth weight infants, the mode of delivery, 16s rRNA gene sequencinghttp://www.sciencedirect.com/science/article/pii/S1875957219305273 |
| spellingShingle | Hongping Li Yong Zhang Bin Xiao Shanqiu Xiao Jiaman Wu Weimin Huang Impacts of delivery mode on very low birth weight infants’ oral microbiome Pediatrics and Neonatology |
| title | Impacts of delivery mode on very low birth weight infants’ oral microbiome |
| title_full | Impacts of delivery mode on very low birth weight infants’ oral microbiome |
| title_fullStr | Impacts of delivery mode on very low birth weight infants’ oral microbiome |
| title_full_unstemmed | Impacts of delivery mode on very low birth weight infants’ oral microbiome |
| title_short | Impacts of delivery mode on very low birth weight infants’ oral microbiome |
| title_sort | impacts of delivery mode on very low birth weight infants oral microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S1875957219305273 |
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