Energy and Dynamics of Caveolae Trafficking
Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane domain is characterized and formed by specific lipid binding proteins including Caveolins, Cavins, Pacsin2, and EHD2. Likewise, an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.614472/full |
| _version_ | 1818600209238720512 |
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| author | Claudia Matthaeus Justin W. Taraska |
| author_facet | Claudia Matthaeus Justin W. Taraska |
| author_sort | Claudia Matthaeus |
| collection | DOAJ |
| description | Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane domain is characterized and formed by specific lipid binding proteins including Caveolins, Cavins, Pacsin2, and EHD2. Likewise, an enrichment of cholesterol and other lipids makes caveolae a distinct membrane environment that supports proteins involved in cell-type specific signaling pathways. Their ability to detach from the plasma membrane and move through the cytosol has been shown to be important for lipid trafficking and metabolism. Here, we review recent concepts in caveolae trafficking and dynamics. Second, we discuss how ATP and GTP-regulated proteins including dynamin and EHD2 control caveolae behavior. Throughout, we summarize the potential physiological and cell biological roles of caveolae internalization and trafficking and highlight open questions in the field and future directions for study. |
| first_indexed | 2024-12-16T12:31:51Z |
| format | Article |
| id | doaj.art-303601eb30114be19a3e98ab9a72db0d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T12:31:51Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-303601eb30114be19a3e98ab9a72db0d2022-12-21T22:31:40ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01810.3389/fcell.2020.614472614472Energy and Dynamics of Caveolae TraffickingClaudia MatthaeusJustin W. TaraskaCaveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane domain is characterized and formed by specific lipid binding proteins including Caveolins, Cavins, Pacsin2, and EHD2. Likewise, an enrichment of cholesterol and other lipids makes caveolae a distinct membrane environment that supports proteins involved in cell-type specific signaling pathways. Their ability to detach from the plasma membrane and move through the cytosol has been shown to be important for lipid trafficking and metabolism. Here, we review recent concepts in caveolae trafficking and dynamics. Second, we discuss how ATP and GTP-regulated proteins including dynamin and EHD2 control caveolae behavior. Throughout, we summarize the potential physiological and cell biological roles of caveolae internalization and trafficking and highlight open questions in the field and future directions for study.https://www.frontiersin.org/articles/10.3389/fcell.2020.614472/fullcaveolaecaveolindynaminEHD2membrane traffickinglipid trafficking |
| spellingShingle | Claudia Matthaeus Justin W. Taraska Energy and Dynamics of Caveolae Trafficking Frontiers in Cell and Developmental Biology caveolae caveolin dynamin EHD2 membrane trafficking lipid trafficking |
| title | Energy and Dynamics of Caveolae Trafficking |
| title_full | Energy and Dynamics of Caveolae Trafficking |
| title_fullStr | Energy and Dynamics of Caveolae Trafficking |
| title_full_unstemmed | Energy and Dynamics of Caveolae Trafficking |
| title_short | Energy and Dynamics of Caveolae Trafficking |
| title_sort | energy and dynamics of caveolae trafficking |
| topic | caveolae caveolin dynamin EHD2 membrane trafficking lipid trafficking |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.614472/full |
| work_keys_str_mv | AT claudiamatthaeus energyanddynamicsofcaveolaetrafficking AT justinwtaraska energyanddynamicsofcaveolaetrafficking |