The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015
Mumps and rubella are vaccine-preventable viral diseases through the measles-mumps-rubella-varicella (MMRV) vaccine, administered at 12 months and again at 6 years. We assessed the sero-prevalence of mumps and rubella, identified factors associated with sero-negativity, and evaluated concordance bet...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/7/996 |
| _version_ | 1797443280238018560 |
|---|---|
| author | Ravit Bassal Tamy Shohat Tal Levin Rakefet Pando Eilat Shinar Doron Amichay Mira Barak Anat Ben-Dor Adina Bar-Haim Ella Mendelson Dani Cohen Lital Keinan-Boker Victoria Indenbaum |
| author_facet | Ravit Bassal Tamy Shohat Tal Levin Rakefet Pando Eilat Shinar Doron Amichay Mira Barak Anat Ben-Dor Adina Bar-Haim Ella Mendelson Dani Cohen Lital Keinan-Boker Victoria Indenbaum |
| author_sort | Ravit Bassal |
| collection | DOAJ |
| description | Mumps and rubella are vaccine-preventable viral diseases through the measles-mumps-rubella-varicella (MMRV) vaccine, administered at 12 months and again at 6 years. We assessed the sero-prevalence of mumps and rubella, identified factors associated with sero-negativity, and evaluated concordance between mumps and rubella sero-positivity. A national cross-sectional sero-survey was conducted on samples collected in 2015 by the Israel National Sera Bank. Samples were tested for mumps and rubella IgG antibodies using an enzyme-linked immunosorbent assay. Of 3131 samples tested for mumps IgG, 84.8% (95%CI: 83.5–86.0%) were sero-positive. Sero-negativity for mumps was significantly associated with age (high odds ratios observed in infants younger than 4 years and 20–29 years old subjects). Of 3169 samples tested for rubella IgG antibodies, 95.2% (95%CI: 94.4–95.9%) were sero-positive. Rubella sero-negativity was significantly associated with age (high odds ratios observed in children younger than 4 years old and adults older than 30 years), males, Jews, and others. Concordant sero-positivity for both mumps and rubella viruses was observed in 83.9% of the tested samples. The Israeli population was sufficiently protected against rubella but not against mumps. Since both components are administered in the MMRV vaccine simultaneously, the mumps component has a lower uptake than rubella and quicker waning. |
| first_indexed | 2024-03-09T12:53:40Z |
| format | Article |
| id | doaj.art-3037e373443d4b5fba3609657df6a24d |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:53:40Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-3037e373443d4b5fba3609657df6a24d2023-11-30T22:02:16ZengMDPI AGVaccines2076-393X2022-06-0110799610.3390/vaccines10070996The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015Ravit Bassal0Tamy Shohat1Tal Levin2Rakefet Pando3Eilat Shinar4Doron Amichay5Mira Barak6Anat Ben-Dor7Adina Bar-Haim8Ella Mendelson9Dani Cohen10Lital Keinan-Boker11Victoria Indenbaum12Israel Center for Disease Control, Ministry of Health, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, IsraelIsrael Center for Disease Control, Ministry of Health, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer 52621, IsraelMagen David Adom (MDA) National Blood Services, Tel Hashomer 52621, IsraelSoroka University Medical Center, Clalit Health Services, Beer Sheva 84101, IsraelHaifa and Western Galilee Laboratories, Clalit Health Services, Nesher 20300, IsraelSchneider Children Medical Center, Clalit Health Services, Petah-Tiqwa 49504, IsraelMayanei HaYeshuhai Medical Center, Bnei Brak 51544, IsraelDepartment of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, IsraelDepartment of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, IsraelIsrael Center for Disease Control, Ministry of Health, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer 52621, IsraelMumps and rubella are vaccine-preventable viral diseases through the measles-mumps-rubella-varicella (MMRV) vaccine, administered at 12 months and again at 6 years. We assessed the sero-prevalence of mumps and rubella, identified factors associated with sero-negativity, and evaluated concordance between mumps and rubella sero-positivity. A national cross-sectional sero-survey was conducted on samples collected in 2015 by the Israel National Sera Bank. Samples were tested for mumps and rubella IgG antibodies using an enzyme-linked immunosorbent assay. Of 3131 samples tested for mumps IgG, 84.8% (95%CI: 83.5–86.0%) were sero-positive. Sero-negativity for mumps was significantly associated with age (high odds ratios observed in infants younger than 4 years and 20–29 years old subjects). Of 3169 samples tested for rubella IgG antibodies, 95.2% (95%CI: 94.4–95.9%) were sero-positive. Rubella sero-negativity was significantly associated with age (high odds ratios observed in children younger than 4 years old and adults older than 30 years), males, Jews, and others. Concordant sero-positivity for both mumps and rubella viruses was observed in 83.9% of the tested samples. The Israeli population was sufficiently protected against rubella but not against mumps. Since both components are administered in the MMRV vaccine simultaneously, the mumps component has a lower uptake than rubella and quicker waning.https://www.mdpi.com/2076-393X/10/7/996mumpsrubellasero-prevalencevirusvaccine |
| spellingShingle | Ravit Bassal Tamy Shohat Tal Levin Rakefet Pando Eilat Shinar Doron Amichay Mira Barak Anat Ben-Dor Adina Bar-Haim Ella Mendelson Dani Cohen Lital Keinan-Boker Victoria Indenbaum The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015 Vaccines mumps rubella sero-prevalence virus vaccine |
| title | The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015 |
| title_full | The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015 |
| title_fullStr | The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015 |
| title_full_unstemmed | The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015 |
| title_short | The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015 |
| title_sort | concordance between mumps and rubella sero positivity among the israeli population in 2015 |
| topic | mumps rubella sero-prevalence virus vaccine |
| url | https://www.mdpi.com/2076-393X/10/7/996 |
| work_keys_str_mv | AT ravitbassal theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT tamyshohat theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT tallevin theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT rakefetpando theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT eilatshinar theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT doronamichay theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT mirabarak theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT anatbendor theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT adinabarhaim theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT ellamendelson theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT danicohen theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT litalkeinanboker theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT victoriaindenbaum theconcordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT ravitbassal concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT tamyshohat concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT tallevin concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT rakefetpando concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT eilatshinar concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT doronamichay concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT mirabarak concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT anatbendor concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT adinabarhaim concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT ellamendelson concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT danicohen concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT litalkeinanboker concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 AT victoriaindenbaum concordancebetweenmumpsandrubellaseropositivityamongtheisraelipopulationin2015 |