Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways

Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways

ObjectiveThe aim of this study was to eluc\idate the preventive and therapeutic effects and the underlying mechanisms of Huoxue Huatan Decoction (HXHT) on myocardial ischemia/reperfusion (I/R) injury in hyperlipidemic rats.MethodsAn I/R model was established in hyperlipidemic Wistar rats. After 4–8...

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Bibliographic Details
Main Authors: Fei Lin, Yu-Qing Tan, Xuan-Hui He, Li-Li Guo, Ben-Jun Wei, Jun-Ping Li, Zhong Chen, Heng-Wen Chen, Jie Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
Huoxue Huatan Decoction
hyperlipidemia
ischemia/reperfusion (I/R)
mitochondria
PGC-1α
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.546825/full

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