Incidence of aplastic anemia and agranulocytosis in Latin America: the LATIN study
CONTEXT AND OBJECTIVE: Aplastic anemia and agranulocytosis are rare but life-threatening disorders, often caused by drugs and other environmental exposures. Reported incidence of these diseases seems to vary between different geographic regions, and few data on their incidence are available for Lati...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802005000300002&lng=en&tlng=en |
| _version_ | 1818057402660945920 |
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| author | Nelson Hamerschlak Eliane Maluf Ricardo Pasquini José Eluf-Neto Frederico Rafael Moreira Alexandre Biasi Cavalcanti Íria Ruriko Okano Roberto Passeto Falcão Marimília Teixeira Pita Sandra Regina Loggetto Luiz Gastão Rosenfeld Irene Gyongyvér Heidemarie Lorand-Metze |
| author_facet | Nelson Hamerschlak Eliane Maluf Ricardo Pasquini José Eluf-Neto Frederico Rafael Moreira Alexandre Biasi Cavalcanti Íria Ruriko Okano Roberto Passeto Falcão Marimília Teixeira Pita Sandra Regina Loggetto Luiz Gastão Rosenfeld Irene Gyongyvér Heidemarie Lorand-Metze |
| author_sort | Nelson Hamerschlak |
| collection | DOAJ |
| description | CONTEXT AND OBJECTIVE: Aplastic anemia and agranulocytosis are rare but life-threatening disorders, often caused by drugs and other environmental exposures. Reported incidence of these diseases seems to vary between different geographic regions, and few data on their incidence are available for Latin American countries. The aim of this work is to determine the incidence of agranulocytosis and aplastic anemia in Brazil. DESIGN AND SETTING: Incidence study. Seven centers took part in the pilot phase, so as to represent all Brazilian regions. METHODS: Each center conducted an active search for new cases in a defined region by means of regular contacts with all hematologists, main clinical laboratories and clinicians in hospitals of the region. RESULTS: 74 patients with aplastic anemia and 16 with agranulocytosis were identified. Patients with agranulocytosis had a median age of 31 years (interquartile range, IQR: 12.5-48.2); 32.2% were male and 81.2% were white. The median age of aplastic anemia patients was 21 years (IQR 15.0-35.2); 62.2% were male, 50.0% were white and 39.2% mulatto. The incidence of agranulocytosis was estimated to be 0.5 cases per million individuals per year, ranging from 0.0 to 1.1 cases per million per year between regions. The incidence of aplastic anemia was 2.7 cases per million per year, ranging from 1.1 to 7.1 cases per million per year between regions. CONCLUSIONS: Aplastic anemia and agranulocytosis are rare diseases in Brazil. However, there is considerable variability in their incidences between different regions. |
| first_indexed | 2024-12-10T12:44:10Z |
| format | Article |
| id | doaj.art-303a29ddd667465faff2e1ff569c38e7 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-10T12:44:10Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-303a29ddd667465faff2e1ff569c38e72022-12-22T01:48:26ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460123310110410.1590/S1516-31802005000300002S1516-31802005000300002Incidence of aplastic anemia and agranulocytosis in Latin America: the LATIN studyNelson Hamerschlak0Eliane Maluf1Ricardo Pasquini2José Eluf-Neto3Frederico Rafael Moreira4Alexandre Biasi Cavalcanti5Íria Ruriko Okano6Roberto Passeto Falcão7Marimília Teixeira Pita8Sandra Regina Loggetto9Luiz Gastão Rosenfeld10Irene Gyongyvér Heidemarie Lorand-Metze11Instituto Israelita de Ensino e Pesquisa Albert EinsteinUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade de São PauloInstituto Israelita de Ensino e Pesquisa Albert EinsteinInstituto Israelita de Ensino e Pesquisa Albert EinsteinInstituto Israelita de Ensino e Pesquisa Albert EinsteinUniversidade de São PauloCentro de Hematologia de São PauloCentro de Hematologia de São PauloCentro de Hematologia de São PauloUniversidade Estadual de CampinasCONTEXT AND OBJECTIVE: Aplastic anemia and agranulocytosis are rare but life-threatening disorders, often caused by drugs and other environmental exposures. Reported incidence of these diseases seems to vary between different geographic regions, and few data on their incidence are available for Latin American countries. The aim of this work is to determine the incidence of agranulocytosis and aplastic anemia in Brazil. DESIGN AND SETTING: Incidence study. Seven centers took part in the pilot phase, so as to represent all Brazilian regions. METHODS: Each center conducted an active search for new cases in a defined region by means of regular contacts with all hematologists, main clinical laboratories and clinicians in hospitals of the region. RESULTS: 74 patients with aplastic anemia and 16 with agranulocytosis were identified. Patients with agranulocytosis had a median age of 31 years (interquartile range, IQR: 12.5-48.2); 32.2% were male and 81.2% were white. The median age of aplastic anemia patients was 21 years (IQR 15.0-35.2); 62.2% were male, 50.0% were white and 39.2% mulatto. The incidence of agranulocytosis was estimated to be 0.5 cases per million individuals per year, ranging from 0.0 to 1.1 cases per million per year between regions. The incidence of aplastic anemia was 2.7 cases per million per year, ranging from 1.1 to 7.1 cases per million per year between regions. CONCLUSIONS: Aplastic anemia and agranulocytosis are rare diseases in Brazil. However, there is considerable variability in their incidences between different regions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802005000300002&lng=en&tlng=enAplastic anemiaAgranulocytosisIncidenceRisk factorsGranulocytes |
| spellingShingle | Nelson Hamerschlak Eliane Maluf Ricardo Pasquini José Eluf-Neto Frederico Rafael Moreira Alexandre Biasi Cavalcanti Íria Ruriko Okano Roberto Passeto Falcão Marimília Teixeira Pita Sandra Regina Loggetto Luiz Gastão Rosenfeld Irene Gyongyvér Heidemarie Lorand-Metze Incidence of aplastic anemia and agranulocytosis in Latin America: the LATIN study São Paulo Medical Journal Aplastic anemia Agranulocytosis Incidence Risk factors Granulocytes |
| title | Incidence of aplastic anemia and agranulocytosis in Latin America: the LATIN study |
| title_full | Incidence of aplastic anemia and agranulocytosis in Latin America: the LATIN study |
| title_fullStr | Incidence of aplastic anemia and agranulocytosis in Latin America: the LATIN study |
| title_full_unstemmed | Incidence of aplastic anemia and agranulocytosis in Latin America: the LATIN study |
| title_short | Incidence of aplastic anemia and agranulocytosis in Latin America: the LATIN study |
| title_sort | incidence of aplastic anemia and agranulocytosis in latin america the latin study |
| topic | Aplastic anemia Agranulocytosis Incidence Risk factors Granulocytes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802005000300002&lng=en&tlng=en |
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