Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway

Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway

Inflammation is a key factor in the development of ulcerative colitis (UC). 1,25-dihydroxyvitamin D3 (1,25(OH)2D3, VD3), as the major active ingredient of vitamin D and an anti-inflammatory activator, is closely related to the initiation and development of UC, but its regulatory mechanism remains un...

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Bibliographic Details
Main Authors: Hongliang Gao, He Zhou, Zhiqiang Zhang, Jianshu Gao, Jian Li, Xinxia Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
VDR
NLRP6 inflammasome
ulcerative colitis
VD3
ATAC-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1135930/full

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