Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically
A post-mortem examined case of herpetic brainstem encephalitis is presented. Clinically, the patient had cephalea followed by ataxia, drowsiness and multiple palsies of some cranial nerves, developing into death in eight days. The pathologic examination of the brain showed necrotizing encephalitis i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
1987-03-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1987000100006&lng=en&tlng=en |
| _version_ | 1819046430970478592 |
|---|---|
| author | José Eymard Homem Pitella Virgínia Hora Rios Leite Marco Aurélio Lana-Peixoto Carlos Eduardo Bacchi |
| author_facet | José Eymard Homem Pitella Virgínia Hora Rios Leite Marco Aurélio Lana-Peixoto Carlos Eduardo Bacchi |
| author_sort | José Eymard Homem Pitella |
| collection | DOAJ |
| description | A post-mortem examined case of herpetic brainstem encephalitis is presented. Clinically, the patient had cephalea followed by ataxia, drowsiness and multiple palsies of some cranial nerves, developing into death in eight days. The pathologic examination of the brain showed necrotizing encephalitis in multiple foci limited to the brainstem, more distinctly in the pons and medula oblongata. The technique of immunoperoxidase revealed rare glial cells with intranuclear immunoreactivity for herpes antigen. Rare viral particles with the morphological characteristics of the herpesvirus were identified in the nuclei of neurons in 10% formol fixed material. This is the second reported case of herpetic brainstem encephalitis confirmed by post-mortem examination. The pathway used by the virus to reach the central nervous system and its posterior dissemination to the oral cavity, the orbitofrontal region and the temporal lobes as well as to the brainstem, after a period of latency and reactivation, are discussed. |
| first_indexed | 2024-12-21T10:44:21Z |
| format | Article |
| id | doaj.art-303b1f2b5c6b4e84b906fb0f82bfdc8c |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-21T10:44:21Z |
| publishDate | 1987-03-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-303b1f2b5c6b4e84b906fb0f82bfdc8c2022-12-21T19:06:51ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42271987-03-01451445210.1590/S0004-282X1987000100006S0004-282X1987000100006Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemicallyJosé Eymard Homem Pitella0Virgínia Hora Rios Leite1Marco Aurélio Lana-Peixoto2Carlos Eduardo Bacchi3Universidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisA post-mortem examined case of herpetic brainstem encephalitis is presented. Clinically, the patient had cephalea followed by ataxia, drowsiness and multiple palsies of some cranial nerves, developing into death in eight days. The pathologic examination of the brain showed necrotizing encephalitis in multiple foci limited to the brainstem, more distinctly in the pons and medula oblongata. The technique of immunoperoxidase revealed rare glial cells with intranuclear immunoreactivity for herpes antigen. Rare viral particles with the morphological characteristics of the herpesvirus were identified in the nuclei of neurons in 10% formol fixed material. This is the second reported case of herpetic brainstem encephalitis confirmed by post-mortem examination. The pathway used by the virus to reach the central nervous system and its posterior dissemination to the oral cavity, the orbitofrontal region and the temporal lobes as well as to the brainstem, after a period of latency and reactivation, are discussed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1987000100006&lng=en&tlng=en |
| spellingShingle | José Eymard Homem Pitella Virgínia Hora Rios Leite Marco Aurélio Lana-Peixoto Carlos Eduardo Bacchi Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically Arquivos de Neuro-Psiquiatria |
| title | Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
| title_full | Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
| title_fullStr | Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
| title_full_unstemmed | Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
| title_short | Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
| title_sort | herpetic brainstem encephalitis report of a post mortem case studied electron microscopically and immunohisiochemically |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1987000100006&lng=en&tlng=en |
| work_keys_str_mv | AT joseeymardhomempitella herpeticbrainstemencephalitisreportofapostmortemcasestudiedelectronmicroscopicallyandimmunohisiochemically AT virginiahorariosleite herpeticbrainstemencephalitisreportofapostmortemcasestudiedelectronmicroscopicallyandimmunohisiochemically AT marcoaureliolanapeixoto herpeticbrainstemencephalitisreportofapostmortemcasestudiedelectronmicroscopicallyandimmunohisiochemically AT carloseduardobacchi herpeticbrainstemencephalitisreportofapostmortemcasestudiedelectronmicroscopicallyandimmunohisiochemically |