Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease

Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease

Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging and AD are associated with apparent metabolic alterations. As developing effective therapeutic interventions to treat AD is clearly in urgent need, the impact of modulating whole-body and intracellular m...

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Bibliographic Details
Main Authors: Steven N. Austad, Scott Ballinger, Thomas W. Buford, Christy S. Carter, Daniel L. Smith, Jr., Victor Darley-Usmar, Jianhua Zhang
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Mitochondrial DNA
Mitochondrial electron transport chain
Mitochondrial quality control
Reactive species
DAMPs
Hexokinase biosynthesis pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352100246X

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http://www.sciencedirect.com/science/article/pii/S221138352100246X

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