Concurrent acute sensorimotor axonal neuropathy and disseminated encephalitis associated with in an adult patient with anti-MOG and anti-sulfatide antibodies: a case report
Acute disseminated encephalomyelitis and Guillain–Barré syndrome refer to post-infectious or post-vaccination inflammatory demyelinating disorders of central and peripheral nervous system, respectively. We report the case of a 60-year-old male patient presenting with irritability, gait difficulty, a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-03-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/17562864241237850 |
| _version_ | 1797260058460946432 |
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| author | Michail Papantoniou Grigorios Panagopoulos |
| author_facet | Michail Papantoniou Grigorios Panagopoulos |
| author_sort | Michail Papantoniou |
| collection | DOAJ |
| description | Acute disseminated encephalomyelitis and Guillain–Barré syndrome refer to post-infectious or post-vaccination inflammatory demyelinating disorders of central and peripheral nervous system, respectively. We report the case of a 60-year-old male patient presenting with irritability, gait difficulty, asymmetric quadriparesis (mostly in his left extremities), distal sensory loss for pain and temperature in left limbs, and reduced tendon reflexes in his upper limbs and absent in his lower limbs, following an upper respiratory tract infection, 3 weeks earlier. Brain magnetic resonance imaging revealed abnormal T2 signal and peripherally enhancing lesions in hemispheres, brainstem, and cerebellum. Nerve conduction studies were compatible with acute motor and sensory axonal neuropathy. Serology revealed positive IgM and IgG antibodies for Chlamydia pneumoniae , and he also tested positive for myelin oligodendrocyte glycoprotein (MOG) and sulfatide antibodies. Treatment with intravenous immunoglobulin and methylprednisolone led to clinical and radiological recovery within weeks. Even though several cases of combined central and peripheral demyelination have been reported before, it is the first case report with seropositive anti-sulfatide and anti-MOG acute sensorimotor axonal neuropathy and disseminated encephalitis associated with C. pneumoniae. |
| first_indexed | 2024-04-24T23:19:17Z |
| format | Article |
| id | doaj.art-303e219961934281b990f21ecd6694fc |
| institution | Directory Open Access Journal |
| issn | 1756-2864 |
| language | English |
| last_indexed | 2024-04-24T23:19:17Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj.art-303e219961934281b990f21ecd6694fc2024-03-17T01:03:19ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28642024-03-011710.1177/17562864241237850Concurrent acute sensorimotor axonal neuropathy and disseminated encephalitis associated with in an adult patient with anti-MOG and anti-sulfatide antibodies: a case reportMichail PapantoniouGrigorios PanagopoulosAcute disseminated encephalomyelitis and Guillain–Barré syndrome refer to post-infectious or post-vaccination inflammatory demyelinating disorders of central and peripheral nervous system, respectively. We report the case of a 60-year-old male patient presenting with irritability, gait difficulty, asymmetric quadriparesis (mostly in his left extremities), distal sensory loss for pain and temperature in left limbs, and reduced tendon reflexes in his upper limbs and absent in his lower limbs, following an upper respiratory tract infection, 3 weeks earlier. Brain magnetic resonance imaging revealed abnormal T2 signal and peripherally enhancing lesions in hemispheres, brainstem, and cerebellum. Nerve conduction studies were compatible with acute motor and sensory axonal neuropathy. Serology revealed positive IgM and IgG antibodies for Chlamydia pneumoniae , and he also tested positive for myelin oligodendrocyte glycoprotein (MOG) and sulfatide antibodies. Treatment with intravenous immunoglobulin and methylprednisolone led to clinical and radiological recovery within weeks. Even though several cases of combined central and peripheral demyelination have been reported before, it is the first case report with seropositive anti-sulfatide and anti-MOG acute sensorimotor axonal neuropathy and disseminated encephalitis associated with C. pneumoniae.https://doi.org/10.1177/17562864241237850 |
| spellingShingle | Michail Papantoniou Grigorios Panagopoulos Concurrent acute sensorimotor axonal neuropathy and disseminated encephalitis associated with in an adult patient with anti-MOG and anti-sulfatide antibodies: a case report Therapeutic Advances in Neurological Disorders |
| title | Concurrent acute sensorimotor axonal neuropathy and disseminated encephalitis associated with in an adult patient with anti-MOG and anti-sulfatide antibodies: a case report |
| title_full | Concurrent acute sensorimotor axonal neuropathy and disseminated encephalitis associated with in an adult patient with anti-MOG and anti-sulfatide antibodies: a case report |
| title_fullStr | Concurrent acute sensorimotor axonal neuropathy and disseminated encephalitis associated with in an adult patient with anti-MOG and anti-sulfatide antibodies: a case report |
| title_full_unstemmed | Concurrent acute sensorimotor axonal neuropathy and disseminated encephalitis associated with in an adult patient with anti-MOG and anti-sulfatide antibodies: a case report |
| title_short | Concurrent acute sensorimotor axonal neuropathy and disseminated encephalitis associated with in an adult patient with anti-MOG and anti-sulfatide antibodies: a case report |
| title_sort | concurrent acute sensorimotor axonal neuropathy and disseminated encephalitis associated with in an adult patient with anti mog and anti sulfatide antibodies a case report |
| url | https://doi.org/10.1177/17562864241237850 |
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