Experience of using photodynamic therapy in the treatment of esophageal cancer
Photodynamic therapy (PDT) is a worthy alternative to surgical esophageal resection or endoscopic mucosal resection and dissection (EMR, ESD) in patients with superficial esophageal cancer with severe concomitant diseases as well as in patients with a common form of esophageal cancer with severe mal...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2019-07-01
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| Series: | Biomedical Photonics |
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| Online Access: | https://www.pdt-journal.com/jour/article/view/314 |
| _version_ | 1797883624182251520 |
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| author | A. N. Tumanina A. A. Polezhaev V. A. Apanasevich L. I. Gurina M. V. Volkov A. Yu Tarasenko E. V. Filonenko |
| author_facet | A. N. Tumanina A. A. Polezhaev V. A. Apanasevich L. I. Gurina M. V. Volkov A. Yu Tarasenko E. V. Filonenko |
| author_sort | A. N. Tumanina |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a worthy alternative to surgical esophageal resection or endoscopic mucosal resection and dissection (EMR, ESD) in patients with superficial esophageal cancer with severe concomitant diseases as well as in patients with a common form of esophageal cancer with severe malignant dysphagia. Patients with superficial (7) and advanced (15) esophageal cancer received PDT as an independent method and as a supplement to complex treatment. Radachlorin was used as a photosensitizer at a dose of 0.6–0.8 mg/kg, administered intravenously 3 hours before irradiation. A PDT session was carried out using a laser with a wavelength of 662 nm. The light dose used was 150–300 J/cm2 . The use of PDT made it possible to achieve the full effect in 7 (100%) patients in the group of superficial (T1a-T1b) esophageal cancer where PDT was either the only method of treatment or in combination with radiation therapy. In the group of patients with stenotic cancer the use of PDT made it possible to achieve full recovery of food intake after recanalization for 20% of patients, and partial – for 66.7%. Thus, complete natural food intake was restored for 86.7% of patients which improved their quality of life. PDT is also a method of choice for cancer of the upper esophagus as esophageal stenting in this situation can cause unwanted subjective sensations. |
| first_indexed | 2024-04-10T03:54:43Z |
| format | Article |
| id | doaj.art-303f834315084b8a932474c677043aa2 |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-04-10T03:54:43Z |
| publishDate | 2019-07-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-303f834315084b8a932474c677043aa22023-03-13T07:12:31ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322019-07-0182192410.24931/2413-9432-2019-8-2-19-24169Experience of using photodynamic therapy in the treatment of esophageal cancerA. N. Tumanina0A. A. Polezhaev1V. A. Apanasevich2L. I. Gurina3M. V. Volkov4A. Yu Tarasenko5E. V. Filonenko6ФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава РоссииПриморский краевой онкологический диспансерПриморский краевой онкологический диспансерФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава РоссииМНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава РоссииPhotodynamic therapy (PDT) is a worthy alternative to surgical esophageal resection or endoscopic mucosal resection and dissection (EMR, ESD) in patients with superficial esophageal cancer with severe concomitant diseases as well as in patients with a common form of esophageal cancer with severe malignant dysphagia. Patients with superficial (7) and advanced (15) esophageal cancer received PDT as an independent method and as a supplement to complex treatment. Radachlorin was used as a photosensitizer at a dose of 0.6–0.8 mg/kg, administered intravenously 3 hours before irradiation. A PDT session was carried out using a laser with a wavelength of 662 nm. The light dose used was 150–300 J/cm2 . The use of PDT made it possible to achieve the full effect in 7 (100%) patients in the group of superficial (T1a-T1b) esophageal cancer where PDT was either the only method of treatment or in combination with radiation therapy. In the group of patients with stenotic cancer the use of PDT made it possible to achieve full recovery of food intake after recanalization for 20% of patients, and partial – for 66.7%. Thus, complete natural food intake was restored for 86.7% of patients which improved their quality of life. PDT is also a method of choice for cancer of the upper esophagus as esophageal stenting in this situation can cause unwanted subjective sensations.https://www.pdt-journal.com/jour/article/view/314фотодинамическая терапиярак пищеводарадахлорин |
| spellingShingle | A. N. Tumanina A. A. Polezhaev V. A. Apanasevich L. I. Gurina M. V. Volkov A. Yu Tarasenko E. V. Filonenko Experience of using photodynamic therapy in the treatment of esophageal cancer Biomedical Photonics фотодинамическая терапия рак пищевода радахлорин |
| title | Experience of using photodynamic therapy in the treatment of esophageal cancer |
| title_full | Experience of using photodynamic therapy in the treatment of esophageal cancer |
| title_fullStr | Experience of using photodynamic therapy in the treatment of esophageal cancer |
| title_full_unstemmed | Experience of using photodynamic therapy in the treatment of esophageal cancer |
| title_short | Experience of using photodynamic therapy in the treatment of esophageal cancer |
| title_sort | experience of using photodynamic therapy in the treatment of esophageal cancer |
| topic | фотодинамическая терапия рак пищевода радахлорин |
| url | https://www.pdt-journal.com/jour/article/view/314 |
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