Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study
Objective: Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. Nigella sativa has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of N. sativa on a bleomycin- induced p...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2018-04-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/article_10265_d1cfa786d65199120d2d71a04b991527.pdf |
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| author | Hamid Reza Poursalehi Mitra Samareh Fekri Fariba Sharififar Ali Mandegary Atefeh Izadi Rahil Mahmoodi Mohammad Hadi Nematollahi Fateme Porgholamhosein Vahideh Ghorani Masome Samareh Fekri |
| author_facet | Hamid Reza Poursalehi Mitra Samareh Fekri Fariba Sharififar Ali Mandegary Atefeh Izadi Rahil Mahmoodi Mohammad Hadi Nematollahi Fateme Porgholamhosein Vahideh Ghorani Masome Samareh Fekri |
| author_sort | Hamid Reza Poursalehi |
| collection | DOAJ |
| description | Objective: Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. Nigella sativa has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of N. sativa on a bleomycin- induced pulmonary fibrosis model. Materials and Methods: This study was carried out using 52 rats. Pulmonary fibrosis was induced by a single endotracheal injection of bleomycin (5 mg/kg). Extract of N. sativa (500 mg/kg per day) or methylprednisolone succinate (4 mg/kg per day) was injected intraperitoneally in two periods (i.e. days 1-14 as early preventive group and days 15-28 days as late preventive group). The lung tissues were histologically examined at the end of each period and inspected for the amount of hydroxyproline and biomarkers of oxidative stress. Results: The pulmonary inflammation and fibrosis were significantly decreased in groups treated with methylprednisolone and N. sativa extract compared to bleomycin group in both early and late prevention groups (p |
| first_indexed | 2024-12-11T15:53:58Z |
| format | Article |
| id | doaj.art-3040d43f0e644065a296c733b9c4f0eb |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-11T15:53:58Z |
| publishDate | 2018-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-3040d43f0e644065a296c733b9c4f0eb2022-12-22T00:59:29ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492018-04-018326327510.22038/ajp.2018.26259.195110265Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental studyHamid Reza Poursalehi0Mitra Samareh Fekri1Fariba Sharififar2Ali Mandegary3Atefeh Izadi4Rahil Mahmoodi5Mohammad Hadi Nematollahi6Fateme Porgholamhosein7Vahideh Ghorani8Masome Samareh Fekri9Physiology Research Center of Kerman University of Medical Sciences, Kerman, IranCardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IranDepartment of Pharmacognosy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, IranDepartment of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Science, Kerman, IranDepartment of Pharmacy, Kerman University of Medical Science, Kerman, IranDepartment of Pharmacy, Kerman University of Medical Science, Kerman, IranHerbal & Traditional Medicines Research Center, Faculty of Pharmacy Kerman University of Medical Sciences, Kerman, IranDepartment of Pharmacy, Kerman University of Medical Science, Kerman, IranNeurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranAssistant Professor of Plant Protection, Departement of agricultureObjective: Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. Nigella sativa has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of N. sativa on a bleomycin- induced pulmonary fibrosis model. Materials and Methods: This study was carried out using 52 rats. Pulmonary fibrosis was induced by a single endotracheal injection of bleomycin (5 mg/kg). Extract of N. sativa (500 mg/kg per day) or methylprednisolone succinate (4 mg/kg per day) was injected intraperitoneally in two periods (i.e. days 1-14 as early preventive group and days 15-28 days as late preventive group). The lung tissues were histologically examined at the end of each period and inspected for the amount of hydroxyproline and biomarkers of oxidative stress. Results: The pulmonary inflammation and fibrosis were significantly decreased in groups treated with methylprednisolone and N. sativa extract compared to bleomycin group in both early and late prevention groups (phttp://ajp.mums.ac.ir/article_10265_d1cfa786d65199120d2d71a04b991527.pdfBleomycinHydroxyprolineNigella SativaPulmonary inflammation Fibrosis |
| spellingShingle | Hamid Reza Poursalehi Mitra Samareh Fekri Fariba Sharififar Ali Mandegary Atefeh Izadi Rahil Mahmoodi Mohammad Hadi Nematollahi Fateme Porgholamhosein Vahideh Ghorani Masome Samareh Fekri Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study Avicenna Journal of Phytomedicine Bleomycin Hydroxyproline Nigella Sativa Pulmonary inflammation Fibrosis |
| title | Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study |
| title_full | Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study |
| title_fullStr | Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study |
| title_full_unstemmed | Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study |
| title_short | Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study |
| title_sort | early and late preventive effect of nigella sativa on the bleomycin induced pulmonary fibrosis in rats an experimental study |
| topic | Bleomycin Hydroxyproline Nigella Sativa Pulmonary inflammation Fibrosis |
| url | http://ajp.mums.ac.ir/article_10265_d1cfa786d65199120d2d71a04b991527.pdf |
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