Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways
Objective Tobacco is one of the most important risk factors for premature death globally. More than 60 toxic chemicals in tobacco can invade the body's various systems. Oral squamous cell carcinoma (OSCC) is a pathological type of oral cancer, accounting for over 90% of oral cancer. A vast quan...
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2019-10-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/tid/,111652,0,2.html |
| _version_ | 1818757818643120128 |
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| author | Xiao ge Jiang |
| author_facet | Xiao ge Jiang |
| author_sort | Xiao ge Jiang |
| collection | DOAJ |
| description | Objective
Tobacco is one of the most important risk factors for premature death globally. More than 60 toxic chemicals in tobacco can invade the body's various systems. Oral squamous cell carcinoma (OSCC) is a pathological type of oral cancer, accounting for over 90% of oral cancer. A vast quantity of scientific, clinical and epidemiological data shows that tobacco is associated with the development of oral squamous cell carcinoma, and its carcinogenic pathways may be complicated.
Methods
We conducted a thorough electronic search by Cochrane, EMBASE and PubMed to identify relevant studies. Studies published up to the end of October 2018 were included. After assessing and selecting articles based on eligibility criteria, studies were classified and elaborated according to the pathogenesis.
Results
Tobacco as an important risk factor can cause epigenetic alteration of oral epithelial cells, inhibit multiple systemic immune functions of the host, and use its toxic metabolites to cause oxidative stress on tissues to reach the purpose of inducing OSCC. In addition, some specific viruses such as EBV, HPV are thought to play roles in the development of OSCC.
Conclusions
Oral cancer ranks eighth among the most common causes of cancer-related deaths worldwide, and tobacco is one the most important carcinogenic factors of OSCC. The review of the literature attempts to provide directions and ideas for future related researches, as well as call on everyone to take efforts to reduce the amount of tobacco consumption. |
| first_indexed | 2024-12-18T06:16:59Z |
| format | Article |
| id | doaj.art-30445cad15fa4b87af96d70725e485dd |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-12-18T06:16:59Z |
| publishDate | 2019-10-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-30445cad15fa4b87af96d70725e485dd2022-12-21T21:18:14ZengEuropean PublishingTobacco Induced Diseases1617-96252019-10-0117110.18332/tid/111652111652Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathwaysXiao ge Jiang0Department of Pediatric Dentistry, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Shanghai, ChinaObjective Tobacco is one of the most important risk factors for premature death globally. More than 60 toxic chemicals in tobacco can invade the body's various systems. Oral squamous cell carcinoma (OSCC) is a pathological type of oral cancer, accounting for over 90% of oral cancer. A vast quantity of scientific, clinical and epidemiological data shows that tobacco is associated with the development of oral squamous cell carcinoma, and its carcinogenic pathways may be complicated. Methods We conducted a thorough electronic search by Cochrane, EMBASE and PubMed to identify relevant studies. Studies published up to the end of October 2018 were included. After assessing and selecting articles based on eligibility criteria, studies were classified and elaborated according to the pathogenesis. Results Tobacco as an important risk factor can cause epigenetic alteration of oral epithelial cells, inhibit multiple systemic immune functions of the host, and use its toxic metabolites to cause oxidative stress on tissues to reach the purpose of inducing OSCC. In addition, some specific viruses such as EBV, HPV are thought to play roles in the development of OSCC. Conclusions Oral cancer ranks eighth among the most common causes of cancer-related deaths worldwide, and tobacco is one the most important carcinogenic factors of OSCC. The review of the literature attempts to provide directions and ideas for future related researches, as well as call on everyone to take efforts to reduce the amount of tobacco consumption.http://www.journalssystem.com/tid/,111652,0,2.htmltobacco useoral healthcell carcinoma |
| spellingShingle | Xiao ge Jiang Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways Tobacco Induced Diseases tobacco use oral health cell carcinoma |
| title | Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways |
| title_full | Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways |
| title_fullStr | Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways |
| title_full_unstemmed | Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways |
| title_short | Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways |
| title_sort | tobacco and oral squamous cell carcinoma a review of carcinogenic pathways |
| topic | tobacco use oral health cell carcinoma |
| url | http://www.journalssystem.com/tid/,111652,0,2.html |
| work_keys_str_mv | AT xiaogejiang tobaccoandoralsquamouscellcarcinomaareviewofcarcinogenicpathways |