Noise-Induced Hearing Loss
Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural hearing loss, after age-related hearing loss, and affects approximately 5% of the world’s population. NIHL is associated with substantial physical, mental, social, and economic impacts at the patient and societal leve...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/6/2347 |
| _version_ | 1797610935346528256 |
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| author | Nirvikalpa Natarajan Shelley Batts Konstantina M. Stankovic |
| author_facet | Nirvikalpa Natarajan Shelley Batts Konstantina M. Stankovic |
| author_sort | Nirvikalpa Natarajan |
| collection | DOAJ |
| description | Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural hearing loss, after age-related hearing loss, and affects approximately 5% of the world’s population. NIHL is associated with substantial physical, mental, social, and economic impacts at the patient and societal levels. Stress and social isolation in patients’ workplace and personal lives contribute to quality-of-life decrements which may often go undetected. The pathophysiology of NIHL is multifactorial and complex, encompassing genetic and environmental factors with substantial occupational contributions. The diagnosis and screening of NIHL are conducted by reviewing a patient’s history of noise exposure, audiograms, speech-in-noise test results, and measurements of distortion product otoacoustic emissions and auditory brainstem response. Essential aspects of decreasing the burden of NIHL are prevention and early detection, such as implementation of educational and screening programs in routine primary care and specialty clinics. Additionally, current research on the pharmacological treatment of NIHL includes anti-inflammatory, antioxidant, anti-excitatory, and anti-apoptotic agents. Although there have been substantial advances in understanding the pathophysiology of NIHL, there remain low levels of evidence for effective pharmacotherapeutic interventions. Future directions should include personalized prevention and targeted treatment strategies based on a holistic view of an individual’s occupation, genetics, and pathology. |
| first_indexed | 2024-03-11T06:21:53Z |
| format | Article |
| id | doaj.art-304682d5ceea4e15a97555250aaebcbc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:21:53Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-304682d5ceea4e15a97555250aaebcbc2023-11-17T11:51:37ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126234710.3390/jcm12062347Noise-Induced Hearing LossNirvikalpa Natarajan0Shelley Batts1Konstantina M. Stankovic2Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, CA 94304, USADepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, CA 94304, USADepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, CA 94304, USANoise-induced hearing loss (NIHL) is the second most common cause of sensorineural hearing loss, after age-related hearing loss, and affects approximately 5% of the world’s population. NIHL is associated with substantial physical, mental, social, and economic impacts at the patient and societal levels. Stress and social isolation in patients’ workplace and personal lives contribute to quality-of-life decrements which may often go undetected. The pathophysiology of NIHL is multifactorial and complex, encompassing genetic and environmental factors with substantial occupational contributions. The diagnosis and screening of NIHL are conducted by reviewing a patient’s history of noise exposure, audiograms, speech-in-noise test results, and measurements of distortion product otoacoustic emissions and auditory brainstem response. Essential aspects of decreasing the burden of NIHL are prevention and early detection, such as implementation of educational and screening programs in routine primary care and specialty clinics. Additionally, current research on the pharmacological treatment of NIHL includes anti-inflammatory, antioxidant, anti-excitatory, and anti-apoptotic agents. Although there have been substantial advances in understanding the pathophysiology of NIHL, there remain low levels of evidence for effective pharmacotherapeutic interventions. Future directions should include personalized prevention and targeted treatment strategies based on a holistic view of an individual’s occupation, genetics, and pathology.https://www.mdpi.com/2077-0383/12/6/2347noise-induced hearing losssensorineural hearing losscochlear hair celldiagnosispreventionscreening |
| spellingShingle | Nirvikalpa Natarajan Shelley Batts Konstantina M. Stankovic Noise-Induced Hearing Loss Journal of Clinical Medicine noise-induced hearing loss sensorineural hearing loss cochlear hair cell diagnosis prevention screening |
| title | Noise-Induced Hearing Loss |
| title_full | Noise-Induced Hearing Loss |
| title_fullStr | Noise-Induced Hearing Loss |
| title_full_unstemmed | Noise-Induced Hearing Loss |
| title_short | Noise-Induced Hearing Loss |
| title_sort | noise induced hearing loss |
| topic | noise-induced hearing loss sensorineural hearing loss cochlear hair cell diagnosis prevention screening |
| url | https://www.mdpi.com/2077-0383/12/6/2347 |
| work_keys_str_mv | AT nirvikalpanatarajan noiseinducedhearingloss AT shelleybatts noiseinducedhearingloss AT konstantinamstankovic noiseinducedhearingloss |