Posterior reversible leukoencephalopathy syndrome in children with hematologic disorders
Objective: Posterior reversible leukoencephalopathy syndrome (PRES) is characterized by headache, altered mental status, cortical blindness, and seizures associated with neuroradiological findings. It involves predominantly white matter of the parieto-occipital lobes. Several medications and disorde...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2010-09-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-62681 |
| _version_ | 1797699336693350400 |
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| author | Barış Malbora Zekai Avcı Fulden Dönmez Bülent Alioğlu Esra Baskın Füsun Alehan Namık Özbek |
| author_facet | Barış Malbora Zekai Avcı Fulden Dönmez Bülent Alioğlu Esra Baskın Füsun Alehan Namık Özbek |
| author_sort | Barış Malbora |
| collection | DOAJ |
| description | Objective: Posterior reversible leukoencephalopathy syndrome (PRES) is characterized by headache, altered mental status, cortical blindness, and seizures associated with neuroradiological findings. It involves predominantly white matter of the parieto-occipital lobes. Several medications and disorders play a role in the etiology of PRES. In this study, we aimed to show how the prognosis of PRES in hematological diseases of childhood might be according to the etiological factors.Materials and Methods: Here, we report PRES in six patients, aged 4 to 14 years, with diagnoses of leukemia and aplastic anemia. Results: Suggested causes in our patients were chemotherapeutics, hypertension, infection and antimicrobial drug administration, tumor lysis syndrome, acute renal failure and hemodialysis, immunosuppressive drug administration, and hypomagnesemia. One of the patients died of sepsis, renal failure and pulmonary hemorrhage and another died of relapse after total recovery from PRES. The other four patients are under follow-up without problems. Conclusion: We suggest that PRES can recover fully with early diagnosis and treatment whereas it can show poor prognosis depending on the etiology. |
| first_indexed | 2024-03-12T04:06:34Z |
| format | Article |
| id | doaj.art-3047afb09eab41949a0b9a22cf3ef349 |
| institution | Directory Open Access Journal |
| issn | 1300-7777 1308-5263 |
| language | English |
| last_indexed | 2024-03-12T04:06:34Z |
| publishDate | 2010-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-3047afb09eab41949a0b9a22cf3ef3492023-09-03T11:16:30ZengGalenos Publishing HouseTurkish Journal of Hematology1300-77771308-52632010-09-012703168176Posterior reversible leukoencephalopathy syndrome in children with hematologic disordersBarış MalboraZekai AvcıFulden DönmezBülent AlioğluEsra BaskınFüsun AlehanNamık ÖzbekObjective: Posterior reversible leukoencephalopathy syndrome (PRES) is characterized by headache, altered mental status, cortical blindness, and seizures associated with neuroradiological findings. It involves predominantly white matter of the parieto-occipital lobes. Several medications and disorders play a role in the etiology of PRES. In this study, we aimed to show how the prognosis of PRES in hematological diseases of childhood might be according to the etiological factors.Materials and Methods: Here, we report PRES in six patients, aged 4 to 14 years, with diagnoses of leukemia and aplastic anemia. Results: Suggested causes in our patients were chemotherapeutics, hypertension, infection and antimicrobial drug administration, tumor lysis syndrome, acute renal failure and hemodialysis, immunosuppressive drug administration, and hypomagnesemia. One of the patients died of sepsis, renal failure and pulmonary hemorrhage and another died of relapse after total recovery from PRES. The other four patients are under follow-up without problems. Conclusion: We suggest that PRES can recover fully with early diagnosis and treatment whereas it can show poor prognosis depending on the etiology.http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-62681Acute leukemiaaplastic anemiaposterior reversible leukoencephalopathy syndrometumor lysis syndrome |
| spellingShingle | Barış Malbora Zekai Avcı Fulden Dönmez Bülent Alioğlu Esra Baskın Füsun Alehan Namık Özbek Posterior reversible leukoencephalopathy syndrome in children with hematologic disorders Turkish Journal of Hematology Acute leukemia aplastic anemia posterior reversible leukoencephalopathy syndrome tumor lysis syndrome |
| title | Posterior reversible leukoencephalopathy syndrome in children with hematologic disorders |
| title_full | Posterior reversible leukoencephalopathy syndrome in children with hematologic disorders |
| title_fullStr | Posterior reversible leukoencephalopathy syndrome in children with hematologic disorders |
| title_full_unstemmed | Posterior reversible leukoencephalopathy syndrome in children with hematologic disorders |
| title_short | Posterior reversible leukoencephalopathy syndrome in children with hematologic disorders |
| title_sort | posterior reversible leukoencephalopathy syndrome in children with hematologic disorders |
| topic | Acute leukemia aplastic anemia posterior reversible leukoencephalopathy syndrome tumor lysis syndrome |
| url | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-62681 |
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