Starvation marrow – gelatinous transformation of bone marrow
Gelatinous bone marrow transformation (GMT), also known as starvation marrow, represents a rare pathological entity of unclear etiology, in which bone marrow histopathology demonstrates hypoplasia, fat atrophy, and gelatinous infiltration. The finding of gelatinous marrow transformation lacks diseas...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2014-09-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://www.jchimp.net/index.php/jchimp/article/download/24811/pdf_1 |
| _version_ | 1797967358753505280 |
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| author | Eric Osgood Salman Muddassir Minal Jaju Robert Moser Farwa Farid Nishith Mewada |
| author_facet | Eric Osgood Salman Muddassir Minal Jaju Robert Moser Farwa Farid Nishith Mewada |
| author_sort | Eric Osgood |
| collection | DOAJ |
| description | Gelatinous bone marrow transformation (GMT), also known as starvation marrow, represents a rare pathological entity of unclear etiology, in which bone marrow histopathology demonstrates hypoplasia, fat atrophy, and gelatinous infiltration. The finding of gelatinous marrow transformation lacks disease specificity; rather, it is an indicator of severe illness and a marker of poor nutritional status, found in patients with eating disorders, acute febrile illnesses, acquired immunodeficiency syndrome, alcoholism, malignancies, and congestive heart failure. We present a middle-aged woman with a history of alcoholism, depression, and anorexia nervosa who presented with failure to thrive and macrocytic anemia, with bone marrow examination demonstrative of gelatinous transformation, all of which resolved with appropriate treatment. To our knowledge, there are very few cases of GMT which have been successfully treated; thus, our case highlights the importance of proper supportive management. |
| first_indexed | 2024-04-11T02:28:54Z |
| format | Article |
| id | doaj.art-304b8d36aa754116a6f54f5d3ffa287a |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T02:28:54Z |
| publishDate | 2014-09-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-304b8d36aa754116a6f54f5d3ffa287a2023-01-02T21:45:54ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662014-09-01401510.3402/jchimp.v4.2481124811Starvation marrow – gelatinous transformation of bone marrowEric Osgood0Salman Muddassir1Minal Jaju2Robert Moser3Farwa Farid4Nishith Mewada5 St. Francis Medical Center, Department of Internal Medicine, Seton Hall University School of Graduate Medical Sciences, South Orange, NJ, USA St. Francis Medical Center, Department of Medicine, Seton Hall University School of Graduate Medical Sciences, South Orange, NJ, USA St. Francis Medical Center, Department of Internal Medicine, Seton Hall University School of Graduate Medical Sciences, South Orange, NJ, USA St. Francis Medical Center Department of Pathology, Johns Hopkins University, South Orange, NJ, USA Rawalpindi Medical College, Department of Radiology, Holy Family Hospital, Rawalpindi, Pakistan St. Francis Medical Center, Department of Internal Medicine, Seton Hall University School of Graduate Medical Sciences, South Orange, NJ, USAGelatinous bone marrow transformation (GMT), also known as starvation marrow, represents a rare pathological entity of unclear etiology, in which bone marrow histopathology demonstrates hypoplasia, fat atrophy, and gelatinous infiltration. The finding of gelatinous marrow transformation lacks disease specificity; rather, it is an indicator of severe illness and a marker of poor nutritional status, found in patients with eating disorders, acute febrile illnesses, acquired immunodeficiency syndrome, alcoholism, malignancies, and congestive heart failure. We present a middle-aged woman with a history of alcoholism, depression, and anorexia nervosa who presented with failure to thrive and macrocytic anemia, with bone marrow examination demonstrative of gelatinous transformation, all of which resolved with appropriate treatment. To our knowledge, there are very few cases of GMT which have been successfully treated; thus, our case highlights the importance of proper supportive management.http://www.jchimp.net/index.php/jchimp/article/download/24811/pdf_1gelatinous infiltrationanemiaerythropoiesismucopolysaccharide |
| spellingShingle | Eric Osgood Salman Muddassir Minal Jaju Robert Moser Farwa Farid Nishith Mewada Starvation marrow – gelatinous transformation of bone marrow Journal of Community Hospital Internal Medicine Perspectives gelatinous infiltration anemia erythropoiesis mucopolysaccharide |
| title | Starvation marrow – gelatinous transformation of bone marrow |
| title_full | Starvation marrow – gelatinous transformation of bone marrow |
| title_fullStr | Starvation marrow – gelatinous transformation of bone marrow |
| title_full_unstemmed | Starvation marrow – gelatinous transformation of bone marrow |
| title_short | Starvation marrow – gelatinous transformation of bone marrow |
| title_sort | starvation marrow gelatinous transformation of bone marrow |
| topic | gelatinous infiltration anemia erythropoiesis mucopolysaccharide |
| url | http://www.jchimp.net/index.php/jchimp/article/download/24811/pdf_1 |
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