A Signet Cell Carcinoma of the Ileum: A Rare Differential Diagnosis of Intestinal Pathology with Fistula Mimicking Crohn’s Disease
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death in the USA. Primary signet ring cell carcinoma (SRCC) of the colon and rectum is extremely rare with a reported incidence of less than 1%. Here we present the case of a 41-year-old man wh...
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2022-04-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/3294 |
| _version_ | 1818186919790510080 |
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| author | Gaurav Mohan Harshil Fichadiya Darby Olex-Memoli Divya Krishna Doatrang Du Buket Bagchi Ali Rashidbaigi |
| author_facet | Gaurav Mohan Harshil Fichadiya Darby Olex-Memoli Divya Krishna Doatrang Du Buket Bagchi Ali Rashidbaigi |
| author_sort | Gaurav Mohan |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death in the USA. Primary signet ring cell carcinoma (SRCC) of the colon and rectum is extremely rare with a reported incidence of less than 1%. Here we present the case of a 41-year-old man who presented with abdominal pain, severe microcytic anaemia and a negative faecal occult blood test (FOBT). A CT scan of the abdomen revealed thickening of the terminal ileum and proximal right colon with extensive lymphadenopathy and a fistula tract extending from the terminal ileum to the right buttock. Endoscopic features like cobblestoning of the ileocolic junction along with elevated blood and stool inflammatory markers raised suspicion of Crohn’s disease (CD). However, histopathological study surprisingly revealed primary colorectal signet cell carcinoma (PCRSCC) with no evidence of CD. Cases of simultaneous PCRSCC and CD have been reported, but no clear association has been established. Our case is unique in that it presented with classic clinical features of CD, but PCRSCC without any histological evidence of underlying CD was found on histology. |
| first_indexed | 2024-12-11T23:02:47Z |
| format | Article |
| id | doaj.art-304e2f8542f240218419aa4a1ccda634 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-11T23:02:47Z |
| publishDate | 2022-04-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-304e2f8542f240218419aa4a1ccda6342022-12-22T00:47:02ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942022-04-0110.12890/2022_0032942829A Signet Cell Carcinoma of the Ileum: A Rare Differential Diagnosis of Intestinal Pathology with Fistula Mimicking Crohn’s DiseaseGaurav Mohan0Harshil Fichadiya1Darby Olex-Memoli2Divya Krishna3Doatrang Du4Buket Bagchi5Ali Rashidbaigi6Monmouth Medical Center, Long Branch, NJ, USAMonmouth Medical Center, Long Branch, NJ, USARutgers Robert Wood Johnson Medical School, Brunswick, NJ, USA Rutgers Robert Wood Johnson Medical School, Brunswick, NJ, USA Monmouth Medical Center, Long Branch, NJ, USAMonmouth Medical Center, Long Branch, NJ, USAMonmouth Medical Center, Long Branch, NJ, USAColorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death in the USA. Primary signet ring cell carcinoma (SRCC) of the colon and rectum is extremely rare with a reported incidence of less than 1%. Here we present the case of a 41-year-old man who presented with abdominal pain, severe microcytic anaemia and a negative faecal occult blood test (FOBT). A CT scan of the abdomen revealed thickening of the terminal ileum and proximal right colon with extensive lymphadenopathy and a fistula tract extending from the terminal ileum to the right buttock. Endoscopic features like cobblestoning of the ileocolic junction along with elevated blood and stool inflammatory markers raised suspicion of Crohn’s disease (CD). However, histopathological study surprisingly revealed primary colorectal signet cell carcinoma (PCRSCC) with no evidence of CD. Cases of simultaneous PCRSCC and CD have been reported, but no clear association has been established. Our case is unique in that it presented with classic clinical features of CD, but PCRSCC without any histological evidence of underlying CD was found on histology.https://www.ejcrim.com/index.php/EJCRIM/article/view/3294colon cancersignet cell carcinomacrohn’s disease |
| spellingShingle | Gaurav Mohan Harshil Fichadiya Darby Olex-Memoli Divya Krishna Doatrang Du Buket Bagchi Ali Rashidbaigi A Signet Cell Carcinoma of the Ileum: A Rare Differential Diagnosis of Intestinal Pathology with Fistula Mimicking Crohn’s Disease European Journal of Case Reports in Internal Medicine colon cancer signet cell carcinoma crohn’s disease |
| title | A Signet Cell Carcinoma of the Ileum: A Rare Differential Diagnosis of Intestinal Pathology with Fistula Mimicking Crohn’s Disease |
| title_full | A Signet Cell Carcinoma of the Ileum: A Rare Differential Diagnosis of Intestinal Pathology with Fistula Mimicking Crohn’s Disease |
| title_fullStr | A Signet Cell Carcinoma of the Ileum: A Rare Differential Diagnosis of Intestinal Pathology with Fistula Mimicking Crohn’s Disease |
| title_full_unstemmed | A Signet Cell Carcinoma of the Ileum: A Rare Differential Diagnosis of Intestinal Pathology with Fistula Mimicking Crohn’s Disease |
| title_short | A Signet Cell Carcinoma of the Ileum: A Rare Differential Diagnosis of Intestinal Pathology with Fistula Mimicking Crohn’s Disease |
| title_sort | signet cell carcinoma of the ileum a rare differential diagnosis of intestinal pathology with fistula mimicking crohn s disease |
| topic | colon cancer signet cell carcinoma crohn’s disease |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/3294 |
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