N-terminal acetylation can stabilize proteins independent of their ubiquitination
Abstract The majority of proteins in mammalian cells are modified by covalent attachment of an acetyl-group to the N-terminus (Nt-acetylation). Paradoxically, Nt-acetylation has been suggested to inhibit as well as to promote substrate degradation. Contrasting these findings, proteome-wide stability...
Main Authors: | Bert van de Kooij, Evert de Vries, Rogier W. Rooswinkel, George M. C. Janssen, Frédérique K. Kok, Peter A. van Veelen, Jannie Borst |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-04-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-32380-3 |
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