The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury
Acute kidney injury (AKI) is a frequent disease encountered in the hospital, with a higher incidence in intensive care units. Despite progress in renal replacement therapy, AKI is still associated with early and late complications, especially cardiovascular events and mortality. The role of gut-deri...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/14/5/336 |
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| author | Pauline Caillard Youssef Bennis Isabelle Six Sandra Bodeau Saïd Kamel Gabriel Choukroun Julien Maizel Dimitri Titeca-Beauport |
| author_facet | Pauline Caillard Youssef Bennis Isabelle Six Sandra Bodeau Saïd Kamel Gabriel Choukroun Julien Maizel Dimitri Titeca-Beauport |
| author_sort | Pauline Caillard |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a frequent disease encountered in the hospital, with a higher incidence in intensive care units. Despite progress in renal replacement therapy, AKI is still associated with early and late complications, especially cardiovascular events and mortality. The role of gut-derived protein-bound uremic toxins (PBUTs) in vascular and cardiac dysfunction has been extensively studied during chronic kidney disease (CKD), in particular, that of indoxyl sulfate (IS), para-cresyl sulfate (PCS), and indole-3-acetic acid (IAA), resulting in both experimental and clinical evidence. PBUTs, which accumulate when the excretory function of the kidneys is impaired, have a deleterious effect on and cause damage to cardiovascular tissues. However, the link between PBUTs and the cardiovascular complications of AKI and the pathophysiological mechanisms potentially involved are unclear. This review aims to summarize available data concerning the participation of PBUTs in the early and late cardiovascular complications of AKI. |
| first_indexed | 2024-03-10T01:41:08Z |
| format | Article |
| id | doaj.art-304fe81d4e6048ce82ee476dc2f60b44 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T01:41:08Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-304fe81d4e6048ce82ee476dc2f60b442023-11-23T13:23:06ZengMDPI AGToxins2072-66512022-05-0114533610.3390/toxins14050336The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney InjuryPauline Caillard0Youssef Bennis1Isabelle Six2Sandra Bodeau3Saïd Kamel4Gabriel Choukroun5Julien Maizel6Dimitri Titeca-Beauport7Department of Nephrology, Dialysis and Transplantation, Amiens Medical Center, Amiens 80054, FranceMP3CV Laboratory, UR UPJV 7517, University of Picardy Jules Verne, Amiens 80054, FranceMP3CV Laboratory, UR UPJV 7517, University of Picardy Jules Verne, Amiens 80054, FranceMP3CV Laboratory, UR UPJV 7517, University of Picardy Jules Verne, Amiens 80054, FranceMP3CV Laboratory, UR UPJV 7517, University of Picardy Jules Verne, Amiens 80054, FranceDepartment of Nephrology, Dialysis and Transplantation, Amiens Medical Center, Amiens 80054, FranceMP3CV Laboratory, UR UPJV 7517, University of Picardy Jules Verne, Amiens 80054, FranceDepartment of Nephrology, Dialysis and Transplantation, Amiens Medical Center, Amiens 80054, FranceAcute kidney injury (AKI) is a frequent disease encountered in the hospital, with a higher incidence in intensive care units. Despite progress in renal replacement therapy, AKI is still associated with early and late complications, especially cardiovascular events and mortality. The role of gut-derived protein-bound uremic toxins (PBUTs) in vascular and cardiac dysfunction has been extensively studied during chronic kidney disease (CKD), in particular, that of indoxyl sulfate (IS), para-cresyl sulfate (PCS), and indole-3-acetic acid (IAA), resulting in both experimental and clinical evidence. PBUTs, which accumulate when the excretory function of the kidneys is impaired, have a deleterious effect on and cause damage to cardiovascular tissues. However, the link between PBUTs and the cardiovascular complications of AKI and the pathophysiological mechanisms potentially involved are unclear. This review aims to summarize available data concerning the participation of PBUTs in the early and late cardiovascular complications of AKI.https://www.mdpi.com/2072-6651/14/5/336acute kidney injuryuremic toxinscardiovascular dysfunctionindoxyl sulfatepara-cresyl sulfateindole-3-acetic acid |
| spellingShingle | Pauline Caillard Youssef Bennis Isabelle Six Sandra Bodeau Saïd Kamel Gabriel Choukroun Julien Maizel Dimitri Titeca-Beauport The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury Toxins acute kidney injury uremic toxins cardiovascular dysfunction indoxyl sulfate para-cresyl sulfate indole-3-acetic acid |
| title | The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury |
| title_full | The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury |
| title_fullStr | The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury |
| title_full_unstemmed | The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury |
| title_short | The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury |
| title_sort | role of gut derived protein bound uremic toxins in the cardiovascular complications of acute kidney injury |
| topic | acute kidney injury uremic toxins cardiovascular dysfunction indoxyl sulfate para-cresyl sulfate indole-3-acetic acid |
| url | https://www.mdpi.com/2072-6651/14/5/336 |
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