Metabolismo, oxidação e implicações biológicas do ácido docosahexaenoico em doenças neurodegenerativas
Docosahexaenoic acid (C22:6, n-3, DHA) is a polyunsaturated fatty acid (PUFA) present in large concentrations in the brain and, due to the presence of six double bonds in its structure, is highly susceptible to oxidation by enzymes and reactive oxygen/nitrogen species. The peroxidation of PUFAs has...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2011-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000800021&lng=en&tlng=en |
| _version_ | 1819082152689532928 |
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| author | Patricia Postilione Appolinário Priscilla Bento Mattos Cruz Derogis Tatiana Harumi Yamaguti Sayuri Miyamoto |
| author_facet | Patricia Postilione Appolinário Priscilla Bento Mattos Cruz Derogis Tatiana Harumi Yamaguti Sayuri Miyamoto |
| author_sort | Patricia Postilione Appolinário |
| collection | DOAJ |
| description | Docosahexaenoic acid (C22:6, n-3, DHA) is a polyunsaturated fatty acid (PUFA) present in large concentrations in the brain and, due to the presence of six double bonds in its structure, is highly susceptible to oxidation by enzymes and reactive oxygen/nitrogen species. The peroxidation of PUFAs has been implicated in an increasing number of human disorders, including neurodegenerative diseases. Hence, a better understanding of the metabolism pathways of DHA should provide new insights about its role in neurodegenerative diseases. Here we review the main aspects related to DHA metabolism, as well as, the recent findings showing its association with neurodegenerative diseases. |
| first_indexed | 2024-12-21T20:12:08Z |
| format | Article |
| id | doaj.art-3055dbe742cf4e19967ca56e2a4f7118 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-21T20:12:08Z |
| publishDate | 2011-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-3055dbe742cf4e19967ca56e2a4f71182022-12-21T18:51:44ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642011-01-013481409141610.1590/S0100-40422011000800021S0100-40422011000800021Metabolismo, oxidação e implicações biológicas do ácido docosahexaenoico em doenças neurodegenerativasPatricia Postilione Appolinário0Priscilla Bento Mattos Cruz Derogis1Tatiana Harumi Yamaguti2Sayuri Miyamoto3Universidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloDocosahexaenoic acid (C22:6, n-3, DHA) is a polyunsaturated fatty acid (PUFA) present in large concentrations in the brain and, due to the presence of six double bonds in its structure, is highly susceptible to oxidation by enzymes and reactive oxygen/nitrogen species. The peroxidation of PUFAs has been implicated in an increasing number of human disorders, including neurodegenerative diseases. Hence, a better understanding of the metabolism pathways of DHA should provide new insights about its role in neurodegenerative diseases. Here we review the main aspects related to DHA metabolism, as well as, the recent findings showing its association with neurodegenerative diseases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000800021&lng=en&tlng=endocosahexaenoic acidmetabolismneurodegenerative diseases |
| spellingShingle | Patricia Postilione Appolinário Priscilla Bento Mattos Cruz Derogis Tatiana Harumi Yamaguti Sayuri Miyamoto Metabolismo, oxidação e implicações biológicas do ácido docosahexaenoico em doenças neurodegenerativas Química Nova docosahexaenoic acid metabolism neurodegenerative diseases |
| title | Metabolismo, oxidação e implicações biológicas do ácido docosahexaenoico em doenças neurodegenerativas |
| title_full | Metabolismo, oxidação e implicações biológicas do ácido docosahexaenoico em doenças neurodegenerativas |
| title_fullStr | Metabolismo, oxidação e implicações biológicas do ácido docosahexaenoico em doenças neurodegenerativas |
| title_full_unstemmed | Metabolismo, oxidação e implicações biológicas do ácido docosahexaenoico em doenças neurodegenerativas |
| title_short | Metabolismo, oxidação e implicações biológicas do ácido docosahexaenoico em doenças neurodegenerativas |
| title_sort | metabolismo oxidacao e implicacoes biologicas do acido docosahexaenoico em doencas neurodegenerativas |
| topic | docosahexaenoic acid metabolism neurodegenerative diseases |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000800021&lng=en&tlng=en |
| work_keys_str_mv | AT patriciapostilioneappolinario metabolismooxidacaoeimplicacoesbiologicasdoacidodocosahexaenoicoemdoencasneurodegenerativas AT priscillabentomattoscruzderogis metabolismooxidacaoeimplicacoesbiologicasdoacidodocosahexaenoicoemdoencasneurodegenerativas AT tatianaharumiyamaguti metabolismooxidacaoeimplicacoesbiologicasdoacidodocosahexaenoicoemdoencasneurodegenerativas AT sayurimiyamoto metabolismooxidacaoeimplicacoesbiologicasdoacidodocosahexaenoicoemdoencasneurodegenerativas |